新型布尼亚病毒感染患者临床和血清流行病学特征分析

发布时间：2018-05-24 22:35

本文选题：新布尼亚病毒 + 感染　；参考：《南京医科大学学报(自然科学版)》2015年03期

【摘要】：目的 :分析人感染新型布尼亚病毒的临床特点和血清流行病学特征,为制定预防控制措施提供参考。方法 :依《发热伴血小板减少综合征防治指南(2010版)》诊断标准共收集17例患者,采用双抗原夹心ELISA法检测血清新型布尼亚病毒总抗体,采用实时荧光定量PCR(real-time PCR)法进行病原学诊断。结果:1996年发热伴血小板减少暴发疫情发病11例,2010年对留存的7例患者血清进行复核,5份检出新布尼亚病毒总抗体阳性;2010年对1996年疫情中的4例病例再次采样检测,4份标本新布尼亚病毒总抗体阳性。1996年疫情病例11例,2010~2012年监测发现新布尼亚病毒病例6例,合计17例病例中,死亡5例,重症1例,轻症11例,主要临床特征包括发热(100.00%)、血小板减少(100.00%)、白细胞减少(76.47%)以及出血症状、全身中毒症状等。结论:初步观察新布尼亚病毒感染患者抗体阳性可持续14年以上;该病毒感染临床上包括无症状、轻症、重症和死亡病例;主要临床特征包括发热、血小板减少、白细胞减少、出血和全身中毒症状等。
[Abstract]:Objective: to analyze the clinical and seroepidemiological characteristics of human infection with new Bunia virus, and to provide reference for the prevention and control measures. Methods: a total of 17 patients were collected according to the guidelines for the Prevention and treatment of Fever with Thrombocytopenia Syndrome (2010). The serum total antibodies against Bunia virus were detected by double antigen sandwich ELISA assay. Real-time fluorescence quantitative PCR(real-time method was used for etiological diagnosis. Results: 11 cases of fever with thrombocytopenia occurred in 1996, 5 sera of 7 patients were checked in 2010 to detect positive total antibody to new Bunia virus, and 4 cases in 1996 were re-sampled in 2010. Four specimens were positive for the total antibody to the new Bunia virus, 11 cases of the epidemic cases were detected in 1996 and 6 cases of the new Bunia virus were detected by surveillance from 2010 to 2012. Among the 17 cases, 5 died, 1 severe and 11 mild. The main clinical features included fever 100.00000, thrombocytopenia 100.0000m, leukopenia 76.47m), hemorrhage symptoms and systemic poisoning symptoms. Conclusion: the positive antibody of patients with new Bunia virus infection can be sustained for more than 14 years, the infection includes asymptomatic, mild, severe and death cases, and the main clinical features include fever, thrombocytopenia, leukopenia. Bleeding and systemic poisoning, etc.
【作者单位】：无锡市疾病预防控制中心;南京医科大学公共卫生学院;宜兴市疾病预防控制中心;
【基金】：无锡市科技发展计划项目(CSE01N1120) 无锡市卫生局重大项目(G201201) 宜兴市民生科技示范工程建设推进计划项目(2012-06)
【分类号】：R510

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