医院慢性丙型病毒性肝炎患者进展性肝纤维化的发生率及影响因素研究

发布时间：2018-05-26 18:00

  本文选题：慢性丙型肝炎患者 + 进展性肝纤维化　； 参考：《中国艾滋病性病》2015年05期

【摘要】：目的了解医院慢性丙型病毒性肝炎(简称"丙肝")患者的进展性肝纤维化的发生率和影响因素。方法在北京、河南、吉林、辽宁四个省(直辖市)的4家综合医院中,选取在治的慢性丙肝患者进行问卷调查,内容包括研究对象一般人口学特征、感染途径、行为学特征、治疗情况,并结合病历收集患者的实验室检测等结果。结果共调查慢性丙肝患者359例,其中男性171例(47.6%),女性188例(52.4%),平均年龄(55.1±11.9)岁。有进展性肝纤维化者为218例,发生率为60.7%。多因素Logistic回归分析发现,≥40岁、男性、酒精摄入量≥50克/天、未接受抗病毒治疗、合并感染艾滋病病毒(HIV)/乙型肝炎病毒(HBV),是影响进展性肝纤维化发生的5个主要因素。结论医院慢性丙肝患者进展性肝纤维化的发生率较高,应加强丙肝防治知识宣传,提倡慢性丙肝患者早检测和早治疗,并加强对其饮酒等危险行为的干预,以控制进展性肝纤维化的发生。
[Abstract]:Objective to investigate the incidence and influencing factors of progressive hepatic fibrosis in patients with chronic viral hepatitis C (HCV) in hospital. Methods in four general hospitals of Beijing, Henan, Jilin and Liaoning provinces (municipalities directly under the Central Government), patients with chronic hepatitis C were investigated by questionnaire, including the general demographic characteristics, infection pathway and behavioral characteristics. Treatment, combined with the patient's medical records collected the results of laboratory tests and so on. Results 359 patients with chronic hepatitis C were investigated, 171 of them were male and 188 were female. The average age was 55. 1 卤11. 9 years. There were 218 patients with progressive hepatic fibrosis, the incidence was 60.7. Multivariate Logistic regression analysis showed that over 40 years old, male, alcohol intake 鈮，

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