HBV变异、体细胞变异及相关免疫遗传在肝硬化和肝细胞癌发生中的作用

发布时间：2018-05-27 17:26

本文选题：乙型肝炎病毒 + 突变　；参考：《第二军医大学学报》2015年04期

【摘要】：乙型肝炎病毒(hepatitis B virus,HBV)慢性感染已经成为我国最重要公共卫生问题之一,造成重大的疾病负担。从HBV慢性感染状态到相关肝脏疾病的恶性转化,常需要数十年的慢性过程。由于长期感染,HBV在宿主的免疫压力下,被动选择出适合病毒生存的相关突变,而这些突变又进一步促进肝脏疾病的恶性转化。在HBV引起的慢性炎症微环境的长期刺激下,机体基因组也发生大量的体细胞突变,同时被动选择出适合细胞存活的相关突变。被机体选择出来的HBV变异和机体体细胞变异,均促使细胞向恶性方向转变,表现为"变异-选择-适应"的进化过程。此外,不同个体之间的遗传背景差异对HBV导致的疾病进程至关重要,如STAT通路和HLA相关位点的基因多态性与重要HBV变异的交互作用影响疾病进展。
[Abstract]:Chronic hepatitis B virus (HBV) infection has become one of the most important public health problems in China. The malignant transformation from HBV chronic infection to associated liver disease often takes decades of chronic process. Due to the long-term infection of HBV under the host immune pressure, passive selection of relevant mutations suitable for the survival of the virus, and these mutations further promote the malignant transformation of liver disease. Under the long-term stimulation of chronic inflammatory microenvironment caused by HBV, a large number of somatic mutations were also found in the genome of the organism, and the related mutations suitable for cell survival were also passively selected. The HBV mutation and somatic cell variation, which were selected by the body, promoted the cell to change to the malignant direction, which manifested as the evolution process of "mutation-selection-adaptation". In addition, genetic background differences among individuals are critical to disease progression caused by HBV, such as the interaction between genetic polymorphisms of STAT pathway and HLA related loci and important HBV variations.
【作者单位】：第二军医大学热带医学与公共卫生学系流行病学教研室;
【基金】：国家重点基础研究项目(“973”计划,2015CB554006) 国家自然科学基金重大研究计划重点项目(91129301);国家自然科学基金杰出青年科学基金(81025015);国家自然科学基金(81302492) 上海市自然科学基金(12ZR1453600)~~
【分类号】：R735.7;R512.62

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