河南省HIV新报告感染者和长期感染者的病程进展调查

发布时间：2018-05-28 19:35

本文选题：新报告感染者 + 长期感染者　；参考：《现代预防医学》2015年08期

【摘要】：目的分析河南省不同病程的HIV感染者同时段检测指标变化特征。方法回顾性研究58例新报告感染者和68例长期感染者,分析2组感染者2011年至2013年期间CD4+T淋巴细胞、病毒载量(Viral Load,VL)变化情况。采用In-house方法,探讨2组感染者原发耐药状况。结果新报告感染者的CD4+T淋巴细胞2年内从658(520,829)个/μl下降至394(274,529)个/μl,长期感染者从481(292,626)个/μl降低至385(247,520)个/μl,前者变化差异有统计学意义(Z=36.64,P0.05)。组内比较2组感染者VL差异无统计学意义(Z=0.45,P0.05;Z=0.20,P0.05),组间比较显示长期感染者VL高于新报告感染者,差异有统计学意义(Z=2.38,P0.05;Z=3.16,P0.05)。新报告感染者和长期感染者耐药发生率分别为5.17%(3/58)、11.76%(8/68)。结论新报告感染者病程进展快于长期感染者,应加强全省未治疗感染者的跟踪随访和抗病毒治疗前的耐药检测。
[Abstract]:Objective to analyze the changes of HIV infection index in Henan province at the same time. Methods 58 newly reported infections and 68 long-term infections were studied retrospectively. The changes of CD4 T lymphocytes and viral load were analyzed between 2011 and 2013 in two groups. In-house method was used to investigate the status of primary drug resistance in two groups of patients. Results in 2 years, the number of CD4 T lymphocytes in newly reported infected patients decreased from 658 ~ 520829 / 渭 l to 394 ~ 274529 / 渭 l, and that of long-term infection was reduced from 481n292626 / 渭 l to 385 ~ 247520 / 渭 l. There was a significant difference between the former and Z36.64 / 渭 l / 渭 l. There was no significant difference in VL between the two groups. The comparison between the two groups showed that the VL of long-term infection was higher than that of newly reported infection, and the difference was statistically significant. The incidence of drug resistance in newly reported and long-term infections was 5.17 / 58 / 11.76 / 68, respectively. Conclusion the progress of disease course of newly reported infected persons is faster than that of long term infection. The follow-up of untreated patients and the detection of drug resistance before antiviral therapy should be strengthened in the whole province.
【作者单位】：河南省疾病预防控制中心;
【基金】：河南省医学科技攻关计划省部共建项目(2011010016) 河南省疾病预防控制中心科研基金课题河南省防治艾滋病规模化现场流行病学和干预研究(2012ZX10004905)
【分类号】：R512.91

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