利福平与左氧氟沙星在复治涂阳肺结核治疗中的相互作用

发布时间：2018-06-02 00:50

本文选题：肺结核 + 复治涂阳　；参考：《实用医学杂志》2017年06期

【摘要】：目的:探讨利福平与左氧氟沙星在复治涂阳肺结核治疗中的相互作用。方法:选取我院2013年1月至2015年12月的复治涂阳肺结核患者100例,随机将含利福平为对照组,同时含利福平和左氧氟沙星为研究组各50例,观察两组患者服药0.5、1、2 h后的RFP血药浓度,痰涂片及随访时间为治疗2、5、8、9月末;从而分析利福平与左氧氟沙星在复治涂阳肺结核治疗中的相互作用。结果:患者在服药0.5、1、2 h后研究组和对照组之间的利福平血药浓度波动不明显,差异没有统计学意义(P0.05);随着治疗时间的延长,患者的痰涂阳性逐渐降低,而且治疗2、5、8、9月末两组患者的痰涂阳性率差异存在统计学意义(P0.05);治疗8个月后两组患者的稳定和治疗中的比例差异存在统计学意义(P0.05)。结论:利福平与左氧氟沙星在复治涂阳肺结核治疗中不存在拮抗作用,利福平与左氧氟沙星可以联合用于复治涂阳肺结核治疗。
[Abstract]:Objective: To investigate the interaction between rifampicin and levofloxacin in retreating smear positive pulmonary tuberculosis. Methods: 100 cases of retreated smear positive pulmonary tuberculosis in our hospital from January 2013 to December 2015 were selected and randomly included rifampin as control group, including rifampin and levofloxacin in 50 cases, and two groups of patients were treated with 0.5,1,2 H. The RFP blood concentration, sputum smear and follow-up time were treated at the end of the month of 2,5,8,9, and the interaction between rifampin and levofloxacin in the treatment of retreated smear positive pulmonary tuberculosis was analyzed. Results: there was no significant difference in the fluctuation of rifampin concentration between the study group and the control group after the Administration of 0.5,1,2 H (P0.05); with the treatment, the difference was not statistically significant (P0.05). The positive rate of sputum smear decreased gradually, and the positive rate of sputum smear in the two groups of the two groups at the end of the month was statistically significant (P0.05). The difference in the proportion of the two groups in the stability and treatment of the two groups after 8 months of treatment was statistically significant (P0.05). Rifampicin and levofloxacin can be used in the treatment of relapsed smear positive pulmonary tuberculosis.
【作者单位】：广州市胸科医院第二门诊;
【基金】：2012年省高科技发展专项(编号:2012A030400058) 2012年广州市胸科医院科研立项(编号:2012-XK013)
【分类号】：R521

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