微小RNA作为感染性疾病标志物的研究进展

发布时间：2018-06-04 02:23

本文选题：微小RNA + 感染性疾病　；参考：《中国感染与化疗杂志》2015年04期

【摘要】：正哺乳动物细胞内非编码RNA主要有短小干扰RNA(short interfering RNA,siRNA)、微小RNA(microRNA,miRNA)、核仁内小分子RNA(small nucleolar RNAs,snoRNA)等[1]。miRNA基因构成约3%人类基因组,而人类miRNA总基因数目有数千,据估计,单个的miRNA可调控数百到上千目标基因,因此,人类基因约30%~92%可能是由miRNA调控[2]。1993年,Lee等[3]首先在秀丽隐杆线虫(Caenorhabditis elegans)体内发现了长度为22 nt的非编码小RNA——lin-4,同时发现lin-4 RNA在lin-14基因的3′UTR(非翻译区)内存在着互补位点。进一步研究表明,lin-4 RNA通过与lin-14基因的
[Abstract]:In normal mammalian cells, non-coding RNA mainly consists of short interfering RNA(short interfering siRNAs, small RNAs, RNA(small nucleolar RNAsSsnoRNAs, etc. [1] .miRNAs constitute about 3% of the human genome, while the total number of human miRNA genes is estimated to be several thousand. A single miRNA regulates hundreds to thousands of target genes, so, About 30.2% of human genes may be regulated by miRNA [2]. In 1993, Lee et al. (3) first discovered a small non-coding RNA-lin-4 with a length of 22 NT in Caenorhabditis eleans, and found that lin-4 RNA has complementary sites in 3 UTRs (untranslated region) of lin-14 gene. Further studies have shown that RNA of lin-4 is related to the expression of lin-14 gene.
【作者单位】：首都医科大学附属北京儿童医院感染科;
【分类号】：R51

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