奥司他韦治疗群体性成人甲型H3N2流感

发布时间：2018-06-04 03:36

本文选题：流感 + 人　；参考：《中国新药与临床杂志》2015年04期

【摘要】：目的分析驻闽部队群体性成人甲型H3N2流感的发病特点,并观察奥司他韦治疗的疗效和不良反应。方法对2014年夏季驻闽部队作训期间有流感症状并初筛显示为甲/乙型流感阳性的官兵进行问卷调查,并采用咽拭子病毒核酸检测(RT-PCR)进行诊断。予奥司他韦75 mg,po,bid,疗程2~5 d。观察患者症状、体征、实验室指标的改变,评估治疗效果,记录不良反应发生情况。结果 2014年6月24日至7月21日共纳入85例,均确诊为甲型H3N2流感。患者年龄(22.2±4.6)岁,主要临床表现为发热、咳嗽、咳痰、全身酸痛、咽痛、乏力、头痛等流感样症状。实验室检查表现为淋巴细胞计数减少、C反应蛋白升高。经奥司他韦治疗后,均治愈,患者体温降至正常时间为(2.0±0.4)d。32例(38%)患者发生不良反应,发生率排前3位的为白细胞减少、粒细胞减少、窦性心律不齐。结论本次部队群体性甲型H3N2流感属季节性流感,传染性强,传播速度快,病情相对轻。奥司他韦疗效好,不良反应发生率高于以往报道,最主要表现为白细胞和粒细胞减少。
[Abstract]:Objective to analyze the characteristics of influenza A (H3N2) in adults in Fujian army, and to observe the curative effect and adverse reaction of oseltamivir. Methods A questionnaire survey was conducted among the officers and soldiers who had influenza symptoms during the training period in the summer of 2014 and showed positive for influenza A / B and were diagnosed by throat swab virus nucleic acid detection (RT-PCR). The patients were treated with oseltamivir 75 mg / g pobidopyridine for 2 days and 5 days. Observe the changes of symptoms, signs and laboratory indexes, evaluate the therapeutic effect and record the occurrence of adverse reactions. Results from June 24 to July 21, 2014, 85 cases were diagnosed with H3N2 influenza. The patient was 22. 2 卤4. 6 years old. The main clinical manifestations were fever, cough, expectoration, general soreness, sore throat, fatigue, headache and other flu-like symptoms. Laboratory examination showed that lymphocyte count decreased and C-reactive protein increased. After treatment with oseltamivir, all the patients were cured. The patients' body temperature dropped to normal time was 2. 0 卤0.4)d.32 and 38 patients had adverse reactions. The top 3 cases were leukopenia, granulocytopenia and sinus arrhythmia. Conclusion A H3N2 influenza is a seasonal influenza. Oseltamivir was effective and the incidence of adverse reactions was higher than that previously reported, mainly manifested by leukopenia and granulocytopenia.
【作者单位】：中国人民解放军第二军医大学附属长征医院呼吸内科;中国人民解放军南京军区福州总医院呼吸与危重症医学科;
【分类号】：R511.7

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