2型糖尿病患者结核分枝杆菌感染糖化血红蛋白与T淋巴细胞亚群的水平变化相关性研究

发布时间：2018-06-04 11:22

本文选题：肺结核 + 型糖尿病　；参考：《中华医院感染学杂志》2015年18期

【摘要】：目的探讨2型糖尿病合并结核分枝杆菌感染患者糖化血红蛋白和T淋巴细胞亚群的变化及相关性,为2型糖尿病合并结核分枝杆菌感染患者提供临床治疗参考。方法选取2013年1月-2015年1月医院收治的肺结核合并2型糖尿病患者80例作为观察组,另选同期80例肺结核无糖尿病患者作为对照组,观察两组患者的糖化血红蛋白及T淋巴细胞亚群水平的变化及其相关性。结果观察组患者CD3+、CD4+、CD4+/CD8+均低于对照组患者,CD8+高于对照组患者,两组T淋巴细胞亚群比较差异有统计学意义(P0.05);观察组患者空腹血糖、空腹INS(胰岛素)以及糖化血红蛋白均高于对照组,两组比较差异有统计学意义(P0.05);血糖控制理想的患者其CD3+、CD4+高于血糖较高的患者,而观察组患者的CD8+、CD4+/CD8+均低于对照组患者,两组比较差异有统计学意义(P0.05)。结论结核分枝杆菌感染合并2型糖尿病患者存在T淋巴细胞亚群和糖化血红蛋白的变化,其细胞的免疫功能存在缺陷。
[Abstract]:Objective to investigate the changes of glycosylated hemoglobin and T lymphocyte subsets in patients with type 2 diabetes mellitus complicated with Mycobacterium tuberculosis infection, and to provide reference for clinical treatment of type 2 diabetes mellitus patients with Mycobacterium tuberculosis infection. Methods from January 2013 to January 2015, 80 patients with pulmonary tuberculosis complicated with type 2 diabetes mellitus were selected as observation group and 80 patients without pulmonary tuberculosis as control group. The changes and correlation of glycosylated hemoglobin and T lymphocyte subsets were observed in the two groups. Results the levels of CD3 CD4 / CD8 in the observation group were lower than those in the control group, and the difference of T lymphocyte subsets between the two groups was statistically significant (P 0.05), the fasting blood glucose in the observation group was significantly higher than that in the control group. Fasting insulin (insulin) and glycosylated hemoglobin (HbA1c) were significantly higher in the two groups than in the control group (P 0.05). The patients with ideal blood glucose control had higher CD3 CD 4 than those with high blood sugar, while the patients in the observation group had lower CD8 CD 4 / CD 8 than those in the control group. The difference between the two groups was statistically significant (P 0.05). Conclusion the changes of T lymphocyte subsets and glycosylated hemoglobin were found in patients with type 2 diabetes mellitus and mycobacterium tuberculosis infection, and the immune function of the cells was defective.
【作者单位】：石河子大学医学院第一附属医院感染性疾病科;石河子大学医学院第一附属医院内分泌科;
【基金】：国家自然科学基金资助项目(39770351)
【分类号】：R587.1;R52

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