山东省首起人感染H7N9禽流感聚集性疫情及血凝素基因分析

发布时间：2018-06-04 20:36

本文选题：人感染HN禽流感 + 流行病学　；参考：《中国病原生物学杂志》2015年10期

【摘要】：目的了解山东省首次出现的2例人感染H7N9禽流感疫情特点及病毒血凝素基因变异情况,为制定人感染H7N9禽流感预防控制措施提供科学依据。方法从采集自2例感染者的标本中扩增H7N9禽流感病毒血凝素基因(HA)并测序,获得序列与其他H7N9禽流感病毒血凝素基因进行比对分析,并对该起疫情作流行病学调查。结果对2例确诊病例感染H7N9病毒HA基因的序列分析显示,病毒的受体结合位点均为禽源的,且病毒粒子只存在4个氨基酸位点的变异。结论病例1和病例2感染的H7N9病毒为同一株(核苷酸同源性为100%),与环境分离株H7N9禽流感病毒不属于同一来源(核苷酸同源性99.82%)。本起人禽流感疫情的感染源可能暴露于被H7N9禽流感病毒污染的环境,病例1的传播可能是由环境或禽到人的传播。病例2为有限人传人的可能性最大,即病例1传给病例2,而共同暴露于环境感染的几率较小。因此认为山东省首起H7N9禽流感疫情为输入性疫情,存在有限的人传人。
[Abstract]:Objective to investigate the epidemic characteristics of two cases of human avian influenza infection with H7N9 and the variation of hemagglutinin gene in Shandong province, and to provide scientific basis for the prevention and control of human infection with H7N9 avian influenza. Methods the hemagglutinin gene of H7N9 avian influenza virus was amplified from two infected patients and sequenced. The sequence was compared with other hemagglutinin genes of H7N9 avian influenza virus, and the epidemiological investigation was carried out. Results A sequence analysis of HA gene of H7N9 virus in two confirmed cases showed that the receptor binding sites of the virus were avian origin, and the virus particles had only 4 amino acid sites mutated. Conclusion the H7N9 virus infected in case 1 and case 2 is the same strain (nucleotide homology is 100%), which is not the same source (99.82% nucleotide homology) with the environmental isolate H7N9 avian influenza virus. The infection source of this human avian influenza epidemic may be exposed to the environment contaminated by H7N9 avian influenza virus, and the transmission of case 1 may be from environment or avian to human transmission. Case 2 is most likely to be transmitted from person to person, i.e. case 1 is transmitted to case 2, while co-exposure to environmental infection is less likely. Therefore, the first outbreak of H7N9 avian influenza in Shandong Province is considered to be an imported epidemic, and there are limited human-to-human transmission.
【作者单位】：山东枣庄市疾病预防控制中心;
【分类号】：R511.7

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