746例HIV初筛阳性者确证结果的对比分析

发布时间：2018-06-09 23:13

本文选题：艾滋病 + 筛查试验　；参考：《热带医学杂志》2016年03期

【摘要】：目的分析746例HIV初筛阳性标本的确证结果,探讨筛查阳性与确证结果之间的关系。方法对746例HIV初筛阳性标本的ELISA、GICA及WB检测结果进行比较分析。结果746例初筛阳性标本经ELISA、GICA复检后阳性标本714例,再经WB确证后674例为HIV-1抗体阳性,筛查阳性标本的确证阳性率为94.40%(674/714)。WB条带gp160出现率最高为99.41%,p55出现率最低为55.49%。确证阳性组和不确定组的S/CO值分别为(21.78±2.94)和(15.75±9.00),两者差异无统计学意义(P0.05)。以WB试验结果为判定真阳性与真阴性的金标准,ELISA检测HIV抗体的敏感性为94.93%(674/710),特异性为100.00%(36/36);GICA检测HIV抗体的敏感性为97.68%(674/690),特异性为89.29(50/56),经χ~2检验ELISA与GICA检测结果差异有统计学意义(χ~2=348.60,P0.05)。ELISA阳性WB阴性的标本经核酸检测均为阴性。结论ELISA与GICA检测均为阳性的标本确证阳性率最高,高S/CO值提示感染HIV的可能性较大。
[Abstract]:Objective to analyze the confirmed results of 746 HIV screening positive specimens and to explore the relationship between screening positive and confirmed results. Methods the results of Elisa Gica and WB in 746 HIV positive specimens were compared and analyzed. Results 746 positive specimens were examined by Elisagica and 674 were positive for HIV-1 antibody confirmed by WB. The positive rate of gp160 in screening positive samples was 94.400.674 / 7140.The highest rate of gp160 was 99.41% and the lowest was 55.49%. The S-% CO values of positive and uncertain groups were 21.78 卤2.94 and 15.75 卤9.00, respectively. There was no significant difference between the two groups (P 0.05). The sensitivity of Elisa for the detection of HIV antibody was 94.93, the specificity was 100.0036 / 36GICA, the sensitivity was 97.68 / 674 / 690 and the specificity was 89.29 / 50 / 560.The difference between Elisa and gica by 蠂 2 test was statistically significant. Significance (蠂 2 + 348.60% P0.05N. Elisa positive WB-negative specimens were negative for nucleic acid). Conclusion the positive rate of Elisa and gica is the highest, and the high S / P CO value indicates that HIV infection is more likely.
【作者单位】：西安市疾病预防控制中心;
【分类号】：R512.91

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