醒脑静注射液对老年支原体肺炎患者血清肿瘤坏死因子-α、C反应蛋白水平及免疫功能的影响

发布时间：2018-06-10 06:02

本文选题：支原体肺炎 + 醒脑静注射液　；参考：《中国老年学杂志》2017年13期

【摘要】：目的探究醒脑注射液对老年支原体肺炎患者血清肿瘤坏死因子(TNF)-α、C反应蛋白(CRP)及免疫功能的影响。方法老年支原体肺炎患者86例依据抽签法随机分为治疗组及对照组各43例。对照组给予常规抗感染及对症支持治疗方案;治疗组在常规治疗的基础上给予低剂量醒脑静注射液静脉滴注。观察比较两组治疗前、治疗48、72 h后血清TNF-α、CRP、白细胞介素(IL)-6及呼吸音改变情况、高热、胸闷、气促、胸腔积液、肺不张情况、高热持续时间,咳嗽持续时间、痰中带血时间、住院时间、治愈后复发率及不良反应情况。结果治疗前两组血清TNF-α、CRP、IL-6、呼吸音异常例数、高热例数、胸闷例数、气促例数、胸腔积液例数及肺不张例数比较差异无统计学意义(P0.05);治疗48 h后治疗组TNF-α、CRP、IL-6、呼吸音异常例数、高热例数、胸闷例数及气促例数明显低于对照组(P0.05);治疗72 h后治疗组血清TNF-α、CRP、IL-6呼吸音改变情况、高热例数、胸闷例数、气促例数、胸腔积液例数及肺不张例数明显低于对照组(P0.05);治疗组高热持续时间、咳嗽持续时间、痰中带血时间、住院时间及治愈后复发率明显低于对照组(P0.05);治疗过程中治疗组出现皮疹、恶心及皮肤瘙痒例数与对照组,比较差异无统计学意义(P0.05)。结论应用醒脑静注射液可明显改善老年支原体肺炎患者治疗效果,促进病情恢复,降低症状的持续时间并可提高患者免疫力、降低治疗后复发率,同时无明显不良反应。
[Abstract]:Objective to investigate the effect of Xingnao injection on serum tumor necrosis factor TNF- 伪 -C reactive protein (CRP) and immune function in elderly patients with mycoplasma pneumonia. Methods 86 elderly patients with mycoplasma pneumonia were randomly divided into treatment group (n = 43) and control group (n = 43). The control group was given routine anti-infection and symptomatic support therapy, and the treatment group was given low dose Xingnaojing injection intravenous drip on the basis of routine treatment. The changes of serum TNF- 伪 CRP, interleukin-6 and respiratory sound, high fever, chest tightness, shortness of breath, pleural effusion, atelectasis, duration of high fever, duration of cough, time of blood in sputum were observed and compared between the two groups. Duration of hospitalization, recurrence rate and adverse reactions after cure. Results there was no significant difference in serum TNF- 伪 CRP IL-6, abnormal respiratory tone, hyperpyrexia, chest tightness, shortness of breath, pleural effusion and atelectasis between the two groups before treatment. The number of cases of high fever, chest tightness and shortness of breath were significantly lower than those of control group (P 0.05), and the respiratory sounds of TNF- 伪 CRPIL-6, high fever, chest tightness, shortness of breath were changed in the treatment group 72 hours after treatment. The number of cases of pleural effusion and atelectasis was significantly lower than that of the control group (P 0.05), the duration of high fever, cough, blood in sputum, the time of hospitalization and the recurrence rate after cure in the treatment group were significantly lower than those in the control group (P 0.05). There was no significant difference in the number of cases of nausea and pruritus between the control group and the control group (P 0.05). Conclusion Xingnaojing injection can obviously improve the treatment effect of senile mycoplasma pneumonia patients, promote the recovery of the disease, reduce the duration of symptoms, improve the immunity of the patients, reduce the recurrence rate after treatment, and there is no obvious adverse reaction at the same time.
【作者单位】：衢州市人民医院呼吸科;
【基金】：浙江省公益技术研究社会发展项目(2016C33238)
【分类号】：R563.1

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