青海省德令哈市鼠疫病原学及流行病学特征分析

发布时间：2018-06-19 03:56

本文选题：鼠疫 + 病原学　；参考：《中国病原生物学杂志》2015年12期

【摘要】：目的探讨青海省德令哈市鼠疫菌株生物学特点及流行病学意义,为该地区的鼠疫防治提供科学依据。方法对1995-2014年青海省德令哈市分离的33株鼠疫菌株进行生化试验、毒力测定、毒力因子鉴定、鼠疫菌差异片段(Different Region,DFR)分型等研究。结果 33株被试菌株生物型为古典型、生态型均为青藏高原型,菌株基因型为8型29株(占87.88%),44型2株,1b型1株,5型1株,主要基因组型为8型;被试菌株中81.82%(27/33)的鼠疫菌4个毒力因子俱全;毒力检测结果显示所有被测菌株的鼠疫菌均为强毒株。结论青海省德令哈市分离的鼠疫菌具备青藏高原鼠疫病原体特性,鼠疫菌的毒力强;该地区的鼠疫防治工作不容忽视。
[Abstract]:Objective to investigate the biological characteristics and epidemiological significance of Yersinia pestis strains in Delingha, Qinghai Province, and to provide scientific basis for the prevention and control of plague in this area. Methods 33 strains of Yersinia pestis isolated from 1995 to 2014 in Delingha, Qinghai Province, were studied by biochemical test, virulence factor identification, and differential fragment of Yersinia pestis (Yersinia pestis). Results the biotypes of 33 tested strains were paleotypic and ecotypes were Qinghai-Xizang plateau type. 29 strains of strain genotypes were 8 types (87.88A44, 2 strains) and 1 strain (1 strain, 5 type), and the main genome type was type 8; The four virulence factors of Yersinia pestis in 81.82 and 27 / 33 of the tested strains showed that all of the tested strains were virulent strains of Yersinia pestis. Conclusion Yersinia pestis isolated from Delingha City of Qinghai Province has the characteristics of plague pathogen in Qinghai-Tibet Plateau and its virulence.
【作者单位】：青海省地方病预防控制所鼠疫预防控制科;
【基金】：国家自然科学基金项目(No.81160211)
【分类号】：R516.8

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