生殖器疱疹患者单纯疱疹病毒抗体分布与人乳头瘤病毒及沙眼衣原体感染的相关性研究

发布时间：2018-06-20 10:51

本文选题：生殖器疱疹 + 单纯疱疹病毒　；参考：《中华医院感染学杂志》2017年08期

【摘要】：目的探讨生殖器疱疹患者单纯疱疹病毒(HSV)抗体分布、人乳头瘤病毒(HPV)与生殖器沙眼衣原体(Ct)感染的相关性,为性传播疾病的临床预防诊治提供参考。方法选取2013年1月-2016年6月在医院诊断为生殖器疱疹的患者253例,检测血HSV 1型、HSV 2型特异性IgG及IgM,同时检测宫颈分泌物中HPV及Ct。结果 HSV特异性抗体检测阳性率为100.00%,其中14例为HSV 1型单一感染、204例为HSV 2型单一感染、35例为HSV 1型+2型混合感染;HSV 2型特异性IgG及IgM单纯阳性、IgG+IgM阳性患者分别为236例、1例、2例,HSV 1型特异性IgG及IgM单纯阳性、IgG+IgM阳性患者分别为35例、12例、2例;HPV、Ct阳性患者分别有72例、60例,HPV阳性患者中高危型50例、低危型12例、高危型+低危型混合感染10例;HPV阳性患者与HPV阴性患者、Ct阳性患者与Ct阴性患者比较,差异有统计学意义(P0.05),pearson相关性分析显示HPV与Ct检测阳性率之间有正相关性(P0.05)。结论生殖器疱疹患者HSV抗体以HSV 2型IgG阳性率最高,合并HPV及Ct感染现象多见,两者在生殖器疱疹患者中感染明显存在密切相关性。
[Abstract]:Objective to investigate the relationship between the distribution of HSV antibody and the infection of chlamydia trachomatis (CT) in genital herpes patients, so as to provide reference for clinical diagnosis and treatment of sexually transmitted diseases. Methods 253 cases of genital herpes diagnosed in hospital from January 2013 to June 2016 were selected to detect the specific IgG and IgM of HSV1 and HSV2, as well as HPV and Ctin in cervical secretion. Results the positive rate of HSV specific antibody was 100.00cm, of which 14 cases were HSV1 single infection and 204 cases HSV2 single infection. 35 cases were HSV2 specific IgG and IgM positive IgG positive patients. There were 2 cases of HSV1 specific IgG and 35 cases of simple IgM positive IgG, respectively. There were 72 cases of HPVC positive in 72 cases of HPVCt positive and 50 cases of high risk type in 60 cases of HPVCt positive. There were 12 cases of low risk type and 10 cases of high risk type of mixed infection of HPV-positive and HPV-negative patients. The difference was statistically significant (P 0.05) and Pearson correlation analysis showed that there was a positive correlation between HPV and Ct detection rate (P 0.05). Conclusion the positive rate of HSV antibody was the highest in patients with genital herpes, and the infection of HPV and Ct was more common in the patients with genital herpes, and there was a close correlation between them in the patients with genital herpes.
【作者单位】：河南省南阳市中心医院皮肤科;
【基金】：河南省卫生计生委科技攻关基金资助项目(201406233)
【分类号】：R752.1

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