FA值与ADC值在AIDS脑内结核和弓形虫中的应用

发布时间：2018-06-20 12:19

本文选题：结核 + 脑膜　；参考：《中国临床医学影像杂志》2015年05期

【摘要】：目的:探讨弥散张量成像FA值及ADC值在AIDS脑内机会性感染中的临床诊断价值。方法:收集经临床确诊艾滋病合并脑内结核的患者12例,弓形虫患者10例,均行常规MRI检查、DTI和T1WI增强检查,观察病变特点并测量病变实质区、周围水肿区及对侧正常区ADC值、FA值并分析其统计学差异,ROC曲线分析两值诊断效能。结果:两感染灶实质区、水肿区及正常区ADC值及FA值间均有显著差异(P0.05),与正常区相比,实质区、水肿区ADC值、FA值均有统计学意义(P0.05);两感染灶实质区与水肿区FA值及结核性病灶实质区与水肿区ADC值均有统计学差异(P0.05)。两组间实质区FA值存在差异(t=-5.648,P0.01)。ROC曲线显示ADC值AUC=0.715,FA值AUC=0.914,FA值诊断效能大于ADC值(P0.05)。结论:DTI能为AIDS合并脑内结核及弓形虫感染诊断和鉴别诊断提供更多信息,为临床合理用药提供可靠依据。
[Abstract]:Objective: to evaluate the diagnostic value of diffusive Zhang Liang imaging FA value and ADCs value in opportunistic infection in the brain. Methods: 12 cases of AIDS complicated with cerebral tuberculosis and 10 cases of Toxoplasma gondii were examined by conventional MRI, DTI and T1WI were performed, the characteristics of the lesions were observed and the lesion parenchyma was measured. The ADC value and FA value of peripheral edema area and contralateral normal area were analyzed and the statistical difference was analyzed. Results: there were significant differences in ADC values and FA values between the parenchymal, edema and normal areas of the two infected foci (P 0.05). There were significant differences in ADC value and FA value in edema area (P < 0.05), FA value in parenchymal area and edema area (P < 0.05) and in tuberculous lesion area (P < 0.05). There was a difference between the two groups in the FA value of the parenchymal area. The ADC value AUC0.715 / FA value AUC0.914 / FA value was higher than that of the ADC value (P 0.05). Conclusion the ratio of Toxoplasma gondii and Toxoplasma gondii infection can provide more information for diagnosis and differential diagnosis of AIDS complicated with tuberculosis and toxoplasma infection, and provide reliable evidence for rational use of drugs in clinic.
【作者单位】：新疆医科大学第二附属医院影像中心;
【基金】：新疆维吾尔自治区自然科学基金(No.2014211C087) 乌鲁木齐市科学技术计划(No.Y131310011) 新疆医科大学创新基金(No.XJC201246)
【分类号】：R512.91;R445.2

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