噬菌体对三大耐药菌的防控作用研究进展

发布时间：2018-06-21 04:25

本文选题：噬菌体 + 耐药菌　；参考：《中国抗生素杂志》2017年10期

【摘要】：噬菌体发现之初,便被前苏联和东欧医学界用来治疗细菌感染。但是,随着抗生素时代的到来,人们慢慢忽略了对噬菌体的深入研究。近年来,由于全球耐药菌感染率不断攀升,用抗生素治疗细菌感染面临前所未有的挑战,一系列耐药病原菌的出现,如金黄色葡萄球菌(Staphylococcus aureus)、铜绿假单胞菌(Pseudomonas aeruginosa)、鲍曼不动杆菌(Acinetobacter baumannii)、结核杆菌(Mycobacterium tuberculosis)、粪肠球菌(Enterococcus faecalis),尤其是耐甲氧西林金黄色葡萄球菌(methicillin-resistant S.aureus,MRSA)的出现,使得一些科学家和临床工作者开始把注意力重新集中到噬菌体研究上来,并在这个领域取得了较大进展。大量的实验证明:噬菌体可以有效地提高细菌感染的实验动物的存活率。本文就近几年国内外科研工作者在噬菌体治疗金黄色葡萄球菌、铜绿假单胞菌和鲍曼不动杆菌三大耐药菌领域所取得的进展做一综述。
[Abstract]:Bacteriophage discovery was used by the Soviet Union and Eastern European medicine to treat bacterial infections. However, with the advent of the era of antibiotics, people slowly ignored the in-depth study of bacteriophages. In recent years, because of the increasing infection rate of drug-resistant bacteria in the world, the treatment of bacterial infections with antibiotics is facing unprecedented challenges, and a series of drug-resistant pathogens appear. For example, Staphylococcus aureus, Pseudomonas aeruginosaer, Acinetobacter baumanniiae, Mycobacterium tuberculosisus, Enterococcus faecalisus, especially methicillin-resistant S.aureus MRSA. This has led some scientists and clinicians to refocus their attention on bacteriophage research and have made great progress in this field. A large number of experiments have proved that bacteriophage can effectively improve the survival rate of experimental animals infected by bacteria. In this paper, the advances in bacteriophage treatment of Staphylococcus aureus, Pseudomonas aeruginosa and Acinetobacter baumannii are reviewed.
【作者单位】：大连理工大学生命科学与技术学院;动物性食品安全保障技术教育部工程研究中心;
【基金】：国家海洋公益项目(No.201405003-3)
【分类号】：R515

【相似文献】