复方芪术汤联合HAART治疗AIDS病人的疗效及安全性

发布时间：2018-06-28 19:01

本文选题：复方芪术汤 + 高效抗反转录病毒治疗　；参考：《中国艾滋病性病》2015年02期

【摘要】：目的观察中药复方芪术汤联合高效抗反转录病毒治疗(HAART)对艾滋病(AIDS)病人的临床疗效及安全性。方法收集符合抗病毒标准的AIDS病人共74例,将其分为三组:单用HAART组30例,唐草片联合HAART组22例,复方芪术汤联合HAART组22例。每组均治疗6个月,观察3个月及6个月时CD+4T淋巴细胞(简称CD4细胞)计数、中医证候疗效及治疗过程中有无不良反应。结果唐草片联合HAART组治疗6个月后,对比HAART组CD4细胞差异有统计学意义(P0.05);复方芪术汤联合HAART治疗6个月后,对比HAART组CD4细胞差异有统计学意义(P0.05);复方芪术汤与唐草片两组之间差异无统计学意义(P0.05)。唐草片组、复方芪术汤组治疗3个月、6个月后,对比单用HAART组,中医症状体征积分差异均有统计学意义(P0.05或P0.01)。其中,唐草片组、复方芪术汤组组间差异无统计学意义。唐草片组、复方芪术汤组治疗后3个月和6个月,对比单用HAART组,中医证候疗效差异均有统计学意义(P0.01);两组之间差异无统计学意义。三组病人治疗中血常规、肝功能差异均无统计学意义(P0.05)。结论复方芪术汤联合HAART治疗AIDS病人,对改善中医证候疗效、提高CD4细胞计数有一定作用,与唐草片联合HAART疗效相当。相比于单用HAART治疗方案,复方芪术汤联合HAART无明显不良反应,安全可靠。
[Abstract]:Objective to observe the clinical efficacy and safety of compound Qizu decoction (QZD) combined with highly effective antiretrovirus therapy (HAART) in AIDS patients. Methods 74 AIDS patients who met the antiviral standard were divided into three groups: HAART group (n = 30), Tangcao tablet (n = 22) combined with HAART group (n = 22) and compound Qizhutang (n = 22) combined with HAART group (n = 22). Each group was treated for 6 months. The number of CD4T lymphocytes (CD4 cells) was observed at 3 and 6 months, the curative effect of TCM syndromes and the adverse reactions in the course of treatment were observed. Results after 6 months of treatment, there was a significant difference in CD4 cells between HAART group and Tangcao tablet combined with HAART group (P0.05). Compared with HAART group CD4 cell difference was statistically significant (P0.05); compound Qizhutang and Tangcao tablets had no statistical significance between the two groups (P0.05). Tangcao tablet group, compound Qizu decoction group for 3 months, 6 months later, compared with HAART group, TCM symptoms and signs score differences were statistically significant (P0.05 or P0.01). Among them, Tangcao tablet group and compound Qizu decoction group had no statistical significance. Tangcao tablet group, compound Qizu decoction group 3 months and 6 months after treatment, compared with HAART group, TCM syndromes were significantly different (P0.01), there was no significant difference between the two groups. Three groups of patients in the treatment of blood routine, liver function differences were not statistically significant (P0.05). Conclusion compound Qizhutang combined with HAART has a certain effect on improving TCM syndromes and CD4 cell count, which is similar to Tangcao tablet combined with HAART. Compared with HAART alone, compound Qizu decoction combined with HAART has no obvious adverse reactions and is safe and reliable.
【作者单位】：复旦大学附属上海市公共卫生临床中心中医科;
【基金】：上海申康医院发展中心中医药验方项目(SHDC2012411)~~
【分类号】：R512.91

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