慢性乙型肝炎感染谷丙转氨酶持续正常患者肝脏病理相关因素分析

发布时间：2018-07-01 17:53

  本文选题：慢性乙型肝炎 + 肝脏病理　； 参考：《中华医院感染学杂志》2015年17期

【摘要】：目的分析慢性乙型肝炎(HBV)感染谷丙转氨酶(ALT)持续正常的患者肝脏病理相关因素,为慢性乙型肝炎病情判断提供依据。方法选取2012年5月-2014年6月接受治疗的94例慢性HBV感染ALT持续正常的患者作为研究对象,对患者肝组织病理学、血清HBV-DNA及HBeAg进行检测,分析患者的肝活检病理炎症分级和纤维化分期、年龄、HBV-DNA载量、血清HBeAg与炎症和纤维化的关系。结果 94例患者均存在炎症,51例患者存在纤维化,占54.3%,≥40岁患者的炎症活动度较严重,其中炎症活动度≥3,占66.7%,与其他年龄组相比,差异有统计学意义(P0.05);≥40岁患者的纤维化程度较高,与其他年龄组比较,差异有统计学意义(P0.05);炎症活动度≥3、纤维化分期≥3的患者HBV-DNA载量均高于炎症活动度≤2、纤维化分期≤2的患者,而≥40岁的患者HBV-DNA载量高于其他年龄组,血清HBeAg阴性和阳性组炎症活动度≤2、纤维化分期≤2的病例数与炎症活动度≥3、纤维化分期≥3比较,差异均有统计学意义(P0.05)。结论对于ALT持续正常的慢性HBV感染者均存在不同程度的肝组织病理学的改变,其中40岁、病毒数量及HBeAg阳性患者更要注意,必要时行肝组织活检。
[Abstract]:Objective to analyze the related factors of liver pathology in patients with chronic hepatitis B (HBV) infection with alanine aminotransferase (alt). Methods 94 patients with chronic HBV infection who received treatment from May 2012 to June 2014 were selected as subjects. The liver histopathology, serum HBV-DNA and HBeAg were detected. The relationship between inflammation and fibrosis, age and HBV-DNA load, serum HBeAg and inflammation and fibrosis were analyzed. Results Fibrosis was found in 51 patients (54.3%) in all 94 patients, and the degree of inflammatory activity was more serious in patients over 40 years old. The inflammatory activity degree was 鈮，

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