肝病退黄汤直肠滴入治疗慢性乙型病毒性肝炎高胆红素血症的临床疗效观察

发布时间：2018-07-05 12:46

本文选题：肝病退黄汤 + 高胆红素血症　；参考：《中药药理与临床》2016年06期

【摘要】：目的:探讨肝病退黄汤直肠滴入治疗慢性乙型病毒性肝炎高胆红素血症的临床疗效。方法:50例慢性乙型病毒性肝炎高胆红素血症中医属湿热发黄证患者随机分为两组,对照组25例,治疗组25例。对照组患者给予常规内科综合治疗;治疗组在内科综合治疗基础上给予肝病退黄汤150ml直肠滴入,每日两次,疗程4周。治疗前及治疗4周后比较两组患者的临床转归、血清总胆红素、血清白蛋白、血清前白蛋白、总胆汁酸、凝血酶原活动度、乙肝DNA水平变化。结果:治疗组总有效率为88%,与对照组总有效率80%比较,差异无统计学意义;治疗组有效患者中患者的TBIL、TBA较对照组明显降低,ALB、PA、PTa明显升高;2组患者血清HBV-DNA水平均明显下降,差异无统计学意义。结论:对于慢性乙型病毒性肝炎属湿热发黄患者,在常规内科综合治疗的基础上,给予肝病退黄汤直肠滴入能够明显降低患者胆红素水平,改善肝功能,提高临床疗效。
[Abstract]:Objective: to investigate the clinical effect of treating chronic viral hepatitis B with hyperbilirubinemia by rectum drip. Methods 50 cases of chronic viral hepatitis B with hyperbilirubinemia were randomly divided into two groups: control group (n = 25) and treatment group (n = 25). The patients in the control group were given routine comprehensive medical treatment, and the treatment group was treated with 150ml rectum drip on the basis of comprehensive medical treatment, twice a day for 4 weeks. The clinical outcome, serum total bilirubin, serum albumin, serum prealbumin, total bile acid, prothrombin activity and hepatitis B DNA level were compared before and 4 weeks after treatment. Results: the total effective rate of the treatment group was 88%, which was not significantly different from that of the control group (80%), the TBILB TBA of the effective patients in the treatment group was significantly lower than that of the control group, and the serum HBV-DNA level of the patients in the treatment group was significantly lower than that in the control group. The difference was not statistically significant. Conclusion: chronic viral hepatitis B is a kind of damp-heat yellowish patients. On the basis of routine medical comprehensive treatment, rectal drip of Huanghuang decoction for liver disease can obviously reduce bilirubin level, improve liver function and improve clinical curative effect.
【作者单位】：四川省江油市人民医院中西医结合肝病科;
【分类号】：R512.62

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