重庆地区2型糖尿病患者趾甲真菌病患病率及易感因素研究

发布时间：2018-07-07 07:36

本文选题：2型糖尿病 + 趾甲真菌病　；参考：《重庆医科大学》2013年硕士论文

【摘要】：目的：了解重庆地区2型糖尿病(T2DM)患者趾甲真菌病的患病率，并探讨T2DM患者趾甲真菌病的易感因素及趾甲真菌病与糖尿病足溃疡的关系。方法：纳入2011年7月~2013年1月于我院内分泌内科住院的T2DM患者374例，及300例非糖尿病受试者作为对照组（包括上述T2DM患者的配偶132例及我院体检中心体检的受试者168例）。收集受试者的趾甲甲屑行真菌镜检。采用问卷调查、体格检查、查阅病历等方式收集受试者的性别、年龄、糖尿病病程、高血压史、吸烟史、趾甲真菌病家族史、冠心病史、脑梗塞病史、体重指数、足部溃疡、糖化血红蛋白(HbA1c)、胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-c)、低密度脂蛋白(LDL-c)、血糖、血压、糖尿病并发症情况、足癣等相关资料。用SPSS17.0统计软件进行分析。结果：糖尿病组与对照组平均年龄分别为62.93±11.56岁和57.76±12.51岁，两组趾甲真菌病的患病率分别为49.5%和29.6%（P＜0.05）。年龄亚组分析显示，当年龄＜55岁时，两组间趾甲真菌病的患病率差异无统计学意义（P＞0.05）；年龄≥55岁时，糖尿病组趾甲真菌病患病率较对照组高，差异有统计学意义（P＜0.05）。T2DM患者中趾甲真菌病组的年龄、糖尿病周围神经病变患病率、高血压患病率、足癣患病率及趾甲真菌病家族史的阳性率明显高于无趾甲真菌病组(P＜0.05)。Logistic多因素回归分析表明T2DM患者年龄增加（OR=3.373，95%CI1.698~6.703，P=0.001）、足癣（OR=2.480，95%CI1.005~6.120，P=0.049）、趾甲真菌病家族史（OR=2.643，，95%CI1.416~4.934，P=0.002）是趾甲真菌病的易感因素。T2DM患者中趾甲真菌病并未明显增加糖尿病足溃疡的发生风险（OR=1.027，95%CI0.617~1.708，P=0.918）。结论：T2DM患者趾甲真菌病的患病率较非糖尿病受试者明显增高；T2DM患者趾甲真菌病的易感因素包括年龄增加、足癣、趾甲真菌病家族史；T2DM患者趾甲真菌病与糖尿病足溃疡发生的关系不大。
[Abstract]:Objective: to investigate the prevalence of toenail mycosis in type 2 diabetes mellitus (T2DM) in Chongqing, and to explore the risk factors of toenail mycosis and the relationship between toenail mycosis and diabetic foot ulcer. Methods: from July 2011 to January 2013, 374 patients with T2DM and 300 non-diabetic subjects were included as control group (including 132 spouses of T2DM patients and 168 subjects examined in our physical examination center). The toenails of the subjects were collected for mycological examination. Gender, age, course of diabetes, history of hypertension, history of smoking, family history of toenail mycosis, history of coronary heart disease, history of cerebral infarction, body mass index, foot ulcer were collected by questionnaire, physical examination and medical records. Glycosylated hemoglobin (HbA1c), cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-c), low density lipoprotein (LDL-c), blood glucose, blood pressure, diabetic complications, tinea pedis and so on. SPSS 17.0 statistical software was used to analyze. Results: the average age of diabetic group and control group were 62.93 卤11.56 years old and 57.76 卤12.51 years old respectively. The prevalence rate of toenail mycosis was 49.5% and 29.6% respectively (P < 0.05). The age subgroup analysis showed that there was no significant difference in the prevalence of toenail mycosis between the two groups when the age was less than 55 years old (P > 0.05), and the prevalence rate of toenail mycosis in diabetic group was higher than that in the control group when the age was more than 55 years old. The difference was statistically significant (P < 0.05). The age, the prevalence of diabetic peripheral neuropathy and the prevalence of hypertension in patients with toenail mycosis were significant (P < 0.05). The prevalence of tinea pedis and the positive rate of the family history of toenail mycosis were significantly higher than those of the patients without toenail mycosis (P < 0.05). Logistic multivariate regression analysis showed that the age of T2DM patients increased (OR3.37395 CI 1.6986.703 P0.001), tinea pedis (OR2.480995 CI 1.0056.120 P0.049), and the family history of toenail mycosis (OR2.64395CI1.416164.934P0. 002) were susceptible to toenail mycosis. Toenail mycosis in T2DM patients did not significantly increase the risk of diabetic foot ulcers (OR1.02795CI0.6171.708P0.918). Conclusion the prevalence of toenail mycosis in T2DM patients is significantly higher than that in non-diabetic subjects. The risk factors of toenail mycosis in T2DM patients include age, tinea pedis and family history of toenail mycosis. Toenail mycosis was not associated with diabetic foot ulcer in type 2 DM patients.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R587.2;R519

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