麻痹性痴呆患者海马磁共振波谱研究

发布时间：2018-07-09 21:37

本文选题：麻痹性痴呆 + 梅毒　；参考：《临床神经病学杂志》2015年06期

【摘要】：目的探讨麻痹性痴呆(GPI)患者海马代谢物的变化及磁共振波谱(MRS)对GPI的诊断价值。方法对18例GPI患者(GPI组)、18例无神经系统损害的梅毒患者(普通梅毒组)及20例健康志愿者(对照组)行常规MRI检查,并予以行双侧海马1H-MRS单体素扫描,测量双侧海马N-乙酰天门冬氨酸(NAA)、胆碱复合物(Cho)、肌酸和磷酸肌酸(Cr)和肌醇(MI)的峰下面积,计算NAA/Cr、MI/Cr和Cho/Cr,并比较3组间的差异。结果与对照组比较,GPI组双侧海马NAA/Cr明显降低(均P0.01),MI/Cr明显升高(均P0.05);与普通梅毒组比较,GPI组双侧海马NAA/Cr明显降低(均P0.01),MI/Cr明显升高(均P0.05);而普通梅毒组与对照组比较,各个数据之间无显著性差异(均P0.05)。结论1H-MRS能有效检测GPI患者脑组织物质代谢变化,提示GPI患者海马神经元活性降低、丢失明显,并可能伴有神经胶质细胞的增生;对GPI的诊断提供重要依据。
[Abstract]:Objective to investigate the changes of hippocampal metabolites in patients with paralytic dementia (GPI) and the value of magnetic resonance spectroscopy (Mrs) in the diagnosis of GPI. Methods 18 patients with GPI (GPI group) and 18 patients with syphilis without nervous system damage (normal syphilis group) and 20 healthy volunteers (control group) were examined with conventional MRI and bilateral hippocampal 1H-MRS monosome scan was performed. The subpeak areas of N-acetylaspartate (NAA), choline complex (Cho), creatine and creatine phosphate (Cr) and inositol (MI) in bilateral hippocampus were measured. Results compared with the control group, NAA / Cr in bilateral hippocampus of GPI group was significantly decreased (P0.01) and MIP / Cr was significantly higher in GPI group than that in normal syphilis group (P0.05), while NAA / Cr in bilateral hippocampus in GPI group was significantly lower (P0.01) than that in control group (P0.05), while that in normal syphilis group was significantly higher than that in control group (P0.05). There was no significant difference between the data (P0.05). Conclusion 1H-MRS can effectively detect the changes of substance metabolism in brain tissue of patients with GPI, suggesting that the activity of hippocampal neurons in patients with GPI is decreased, the loss of neurons is obvious, and the proliferation of glial cells may be associated with GPI, which provides an important basis for the diagnosis of GPI.
【作者单位】：福建医科大学附属宁德市医院神经内科;福建医科大学附属宁德市医院影像科;
【基金】：福建省宁德市科技局医药卫生类科技计划项目(20100069)
【分类号】：R759.1;R747.9

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