降脂颗粒剂治疗29例HAART后高脂血症患者的疗效观察

发布时间：2018-07-13 09:22

【摘要】：目的探讨降脂颗粒剂治疗高效抗反转录病毒治疗(HAART)后高脂血症患者的临床疗效。方法采用实用性随机对照研究的实验方法,将58例HAART后高脂血症的受试者随机分为实验组(HAART+中药降脂颗粒)、对照组(HAART+安慰剂),每组29例,同时测定治疗前、治疗后12、24周血脂、肝肾功能等指标。两组均治疗6个月。结果在实验组中,降脂颗粒剂在治疗24周时可以显著降低甘油三酯(TG)的水平,与治疗前比较差异有统计学意义(t=2.601,P=0.013);在治疗12、24周,可提高高密度脂蛋白(HDL-C)的水平,与治疗前比较差异有统计学意义(12周t=-2.562,P=0.016;24周t=-2.450,P=0.021);而对照组总胆固醇、TG、HDL-C、低密度脂蛋白治疗后均无统计学意义。治疗12、24周时,实验组HDL-C的治疗效果比对照组好(12周t=-2.573,P=0.013;24周t=-3.041,P=0.004);治疗24周时,实验组TG的治疗效果比对照组好(t=2.601 P=0.013)。治疗24周时,实验组动脉粥样硬化指数下降与对照组相比差异具有统计学意义(t=-2.707,P=0.01)。结论该降脂颗粒剂治疗HAART后高脂血症可以改善脂代谢异常,减少HAART的不良反应,降低心血管疾病的风险。
[Abstract]:Objective to investigate the clinical efficacy of Jiangzhi granules in treating hyperlipidemia patients after effective antiretrovirus therapy (HAART). Methods Fifty-eight subjects with hyperlipidemia after HAART were randomly divided into experimental group (HAART traditional Chinese medicine Jiangzhi granule) and control group (HAART placebo). Liver and kidney function. Both groups were treated for 6 months. Results in the experimental group, the level of triglyceride (TG) was significantly decreased at 24 weeks after treatment with Jiangzhi granule, and the level of high density lipoprotein (HDL-C) was increased at 1224 weeks after treatment. There was significant difference between the control group and the control group before treatment (12 weeks, t = 2.562, P < 0.016, t = 2.450, P = 0.021), but there was no significant difference between the control group and the control group after the treatment of TGG and HDL-C, low density lipoprotein (LDL) treatment, no significant difference was found between the control group and the control group. The effect of HDL-C in the experimental group was better than that in the control group at the 12th week after treatment (12 weeks, t = 2.573U, P < 0.013), and at 24 weeks, the treatment effect of TG in the experimental group was better than that in the control group (t = 2.601, P = 0.013). The effect of TG in the experimental group was better than that in the control group (t = 2.601 P0. 013). After 24 weeks of treatment, the decrease of atherosclerosis index in the experimental group was significantly lower than that in the control group (t = -2.707, P < 0.01). Conclusion the hyperlipidemia after HAART can improve the abnormal lipid metabolism, reduce the adverse reaction of HAART and reduce the risk of cardiovascular disease.
【作者单位】： 广州医科大学附属广州市第八人民医院;中国中医科学院艾滋病中心;
【基金】：基金项目:降脂颗粒治疗高效抗反转录病毒治疗后脂代谢异常多中心随机对照研究(210507005)~~
【分类号】：R512.91;R589.2
，

本文编号：2118898