艾滋病治疗的研究进展

发布时间：2018-07-13 11:02

【摘要】：艾滋病抗病毒治疗(ART),现已取得很大成效。该病原为致死性疾病,现已成为一种可治可管理的传染病,全球艾滋病病毒感染者/艾滋病(HIV/AIDS)的病例虽仍多达3 800万,但有一半以上已经抗病毒治疗。除了药物治疗外,目前一些新技术新方法如基因组编辑等也已介入艾滋病的治疗,并且在人源化动物试验中业已取得很好的效果。不容置疑,艾滋病终究会被人类控制消除。但随着艾滋病抗病毒治疗的不断发展,最根本的问题也就是HIV潜伏库的问题日益突出,不论是分子治疗、组合治疗都存在这样的问题。因此,不断寻找新的潜伏病毒细胞的标记,缩小病毒潜伏库,是当前艾滋病治疗必须解决的课题。此外,尽管艾滋病的防治取得了很大成绩,但目前全球每天仍有近6 000例HIV/AIDS感染的病例发生。因此,安全有效疫苗的研发,不论在预防领域、还是在临床治疗方面,都有其积极的意义。
[Abstract]:AIDS antiviral treatment (art), has achieved great results. The disease is a fatal disease and has become a treatable and manageable infectious disease. Although the number of HIV / AIDS cases in the world is still as high as 38 million, more than half of them have been treated with antiviral therapy. In addition to drug therapy, some new techniques and methods, such as genome editing, have also been involved in the treatment of AIDS, and have achieved good results in humanized animal experiments. There is no doubt that AIDS will eventually be eliminated by human control. However, with the continuous development of anti-viral treatment, the most fundamental problem is the HIV latent library, no matter the molecular therapy, combination therapy has such a problem. Therefore, it is necessary to search for new latent virus cell markers and reduce virus latent library. In addition, despite the success of AIDS prevention and treatment, there are still nearly 6,000 HIV / AIDS infections every day in the world. Therefore, the development of safe and effective vaccine, both in the field of prevention and clinical treatment, has its positive significance.
【作者单位】：福建省疾病预防控制中心;福建医科大学公共卫生学院;
【基金】：闽科计[2016]9号社会发展引导性(重点)项目资助(No.2016Y0010) 福建省卫生系统中青年骨干人才培养项目(2015-ZQNZD-11)~~
【分类号】：R512.91

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