广东省2010～2013年健康人群C群脑膜炎奈瑟菌抗体水平分析

发布时间：2018-08-03 11:32

【摘要】：目的了解广东省2010~2013年健康人群C群脑膜炎奈瑟菌(Neisseria meningitidis,Nm)抗体水平及变化趋势,为预防控制流行性脑脊髓膜炎(流脑)提供参考。方法按照《全国流脑监测点工作手册(2010年)》要求,并结合广东省实际情况,连续在广州、东莞和韶关市采集健康人群血标本,采用杀菌力试验方法,测定血清中C群Nm抗体。结果 2010~2013年,共采集健康人群血标本3158份。C群Nm抗体阳性率和保护率,分别从2010年的29.83%和27.36%上升到2013年的45.94%和41.61%。健康人群C群Nm抗体阳性率和保护率出生后逐渐降低,3岁前降到最低水平,3岁后明显上升,5~14岁有所降低,15岁以后又缓慢上升。健康人群C群Nm抗体阳性率和保护率从高到低依次为广州、东莞和韶关市。男性的C群Nm抗体阳性率和保护率均高于女性。结论广东省2008年9月将A+C群脑膜炎球菌多糖疫苗纳入国家免疫规划,2010~2013年健康人群C群Nm抗体水平逐年提高,但仍存在年龄、地区和性别差异。
[Abstract]:Objective to investigate the level and trend of Neisseria meningitis Nm antibody in healthy population from 2010 to 2013 in Guangdong Province, and to provide reference for prevention and control of epidemic meningitis (meningitis). Methods according to the requirements of the National work Manual for epidemic Encephalopathy (2010) and the actual situation in Guangdong Province, the blood samples of healthy people were collected in Guangzhou, Dongguan and Shaoguan City continuously. The antibody to group C Nm in serum was determined by germicidal test method. Results from 2010 to 2013, the positive and protective rates of Nm antibody in 3158 healthy blood samples were increased from 29.83% and 27.36% in 2010 to 45.94% and 41.61% in 2013, respectively. The positive rate of Nm antibody and the protective rate of group C antibody in healthy population decreased gradually after birth and decreased to the lowest level before the age of 3 years and increased significantly after the age of 3 years. The age of 514 years decreased and then the rate of protection increased slowly after 15 years of age. The positive rate and protective rate of Nm antibody in healthy population from high to low were Guangzhou, Dongguan and Shaoguan. The positive rate and protective rate of group C Nm antibody in males were higher than those in females. Conclusion the antibody level of group C Nm in healthy population of Guangdong Province increased year by year from 2010 to 2013, but there are still differences in age, region and sex.
【作者单位】：广东省疾病预防控制中心;
【分类号】：R515.2

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