HBV感染对淋巴瘤患者自体外周血造血干细胞采集及植入的影响

发布时间：2018-08-13 14:49

【摘要】：目的:探讨淋巴瘤合并HBV感染对自体外周血造血干细胞采集及移植后造血重建的影响。方法:收集2006年1月至2014年10月西安交通大学医学院第一附属医院40例行自体移植的淋巴瘤患者的临床资料进行回顾性分析及随访。40例患者中8例合并有HBV感染,32例未合并HBV感染,对合并HBV感染者给予预防性应用核苷类似物抗乙肝病毒治疗,观察两组患者采集的单个核细胞数及CD34~+细胞数、造血重建和总生存率及疾病无进展生存率间的差异。结果:40例患者的自体外周血造成血干细胞的采集均达标,两组患者采集的单个核细胞数及CD34~+细胞数无显著性统计学差异,8例合并HBV感染的患者在移植中均无HBV的再激活。至随访结束,合并HBV感染患者1年、3年及5年总生存率和疾病无进展生存率分别为100%、85.7%和57.1%及100%,80%和53.3%,未合并HBV感染患者1年、3年及5年总生存率和疾病无进展生存率分别为100%、88.9%,82.1%及90%,90%和90%。结论:HBV感染对自体外周血造血干细胞的采集和植入可能无影响。预防性应用核苷类似物可有效预防HBV再激活,且对自体外周血造血干细胞采集及植入无影响。
[Abstract]:Objective: to investigate the effect of lymphoma combined with HBV infection on autologous peripheral blood stem cell collection and hematopoietic reconstitution after transplantation. Methods: the clinical data of 40 cases of lymphoma with autologous transplantation in the first affiliated Hospital of Xi'an Jiaotong University Medical College from January 2006 to October 2014 were retrospectively analyzed and 8 of the 40 patients with HBV infection were followed up. 32 cases were not complicated with HBV infection. In order to observe the difference of mononuclear cell count, CD34 ~ cell number, hematopoietic reconstitution and overall survival rate and disease progression survival rate in patients with HBV infection, the prophylactic application of nucleoside analogue against hepatitis B virus (HBV) was performed in the two groups. Results there was no significant difference in the number of mononuclear cells and CD34 ~ cells between the two groups. There was no significant difference in the number of mononuclear cells and CD34 ~ cells between the two groups. There was no reactivation of HBV in 8 patients with HBV infection. Up to the end of the follow-up, The 1-year, 3-year and 5-year overall survival rate and disease progression-free survival rate in patients with HBV infection were 100% and 57.1% and 100% and 53.3%, respectively. The 1-year, 3-year and 5-year overall survival rates and disease-free survival rates in patients with HBV infection were 82.1% and 9090%, respectively. Conclusion the infection of HBV may have no effect on the collection and implantation of autologous peripheral blood stem cells. Prophylactic application of nucleoside analogue can effectively prevent HBV reactivation and has no effect on autologous peripheral blood stem cell collection and implantation.
【作者单位】：西安交通大学医学院第一附属医院血液内科;
【分类号】：R733.1;R512.62

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