绵阳市育龄期妇女乙型肝炎病毒表面抗原与表面抗体的双阴分布现况

发布时间：2018-08-23 10:52

【摘要】：目的了解绵阳市育龄期妇女乙型肝炎病毒表面抗原(HBsAg)与表面抗体(HBsAb)的双阴分布现况,为制定育龄期妇女乙肝控制策略提供科学依据。方法采用多阶段随机抽样方法,抽取绵阳市62 551名15~49岁妇女作为研究对象,对所有研究对象进行问卷调查并采集其血标本,采用酶联免疫吸附试验(ELISA)对血清中HBsAg和HBsAb进行检测,HBsAg和HBsAb检测结果均为阴性判定为易感。结果共62 035名育龄期妇女纳入分析,检测出HBV易感者共28 460名,双阴率为45.88%;15~20岁组HBV表面抗原抗体的双阴性最低;汉族HBV表面抗原抗体的双阴性高于其他民族;农村人口HBV表面抗原抗体的双阴性高于城市人口;丧偶/离异HBV表面抗原抗体的双阴性最高,已婚HBV表面抗原抗体的双阴性最低;农民HBV表面抗原抗体的双阴性最高,医务人员HBV表面抗原抗体的双阴性最低;有乙肝家族史育龄期妇女易感性低于无乙肝家族史者;有乙肝接种史者易感性低于无乙肝接种史者,差异均有统计学意义(P0.005)。结论绵阳市育龄期妇女HBV表面抗原抗体的双阴性较高,应加强对其HBV易感性的监测和接种乙肝疫苗,以减少乙肝母婴传播的概率。
[Abstract]:Objective to investigate the distribution of hepatitis B virus surface antigen (HBsAg) and surface antibody (HBsAb) in Mianyang women in order to provide a scientific basis for the development of HBV control strategy. Methods 62,551 15551 15551 women aged 15 to 49 years old in Mianyang City were selected by multi-stage random sampling. All the subjects were investigated by questionnaire and their blood samples were collected. Serum HBsAg and HBsAb were detected by enzyme linked immunosorbent assay (ELISA). Results A total of 62 035 women of childbearing age were included in the analysis and 28 460 cases of susceptibility to HBV were detected. The double negative rate of HBV surface antigen antibody was the lowest in the group of 15 ~ 20 years of age, and the double negative rate of HBV surface antigen antibody in Han nationality was higher than that in other nationalities. The double negative rate of HBV surface antigen antibody in rural population was higher than that in urban population, the double negative rate of widowed / divorced HBV surface antigen antibody was the highest, that of married HBV surface antigen antibody was the lowest, and that of peasant HBV surface antigen antibody was the highest. The HBV surface antigen antibody of medical staff was the lowest, the susceptibility of women with family history of hepatitis B was lower than that of those without family history of hepatitis B, and the susceptibility of patients with history of hepatitis B inoculation was lower than that of those without inoculation of hepatitis B, the difference was statistically significant (P 0.005). Conclusion the double negative HBV surface antigen and antibody in Mianyang women at childbearing age should be monitored and vaccinated against HBV in order to reduce the probability of mother-to-child transmission of HBV.
【作者单位】：四川大学华西公共卫生学院;四川大学华西医院呼吸与危重症医学科;四川大学华西医院感染性疾病中心;涪城区疾病预防控制中心;江油市疾病预防控制中心;
【基金】：十二·五国家重大科技专项(No.2012ZX10004-901)资助
【分类号】：R512.62;R446.6

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