广西艾滋病患者高效抗逆转录病毒治疗效果和生存时间研究

发布时间：2018-08-28 05:58

【摘要】：目的:研究高效抗逆转录病毒疗法(HAART)治疗HIV感染和艾滋病(AIDS)患者的治疗效果和HAART治疗后患者的生存时间。方法:收集3 100例HIV感染和AIDS患者接受HAART治疗12个月,每月用流式细胞仪Multi SET绝对计数法检测患者CD4+T细胞水平,b DNA法(检测范围1.60 log~6.10 log RNA拷贝/m L)检测血浆HIV-1病毒载量1次,并对患者进行严密的临床观察。结果:治疗后12个月CD4+T细胞计数平均升高430×106/L(P0.01)。病毒载量于治疗后8个月全部降至可测水平(1.70 log拷贝/m L)以下,平均下降45 log拷贝/m L。结论:艾滋病患者经HAART治疗后有极为显著的效果,且经过治疗之后,患者的生存率与相关文献比较有很大的提高。
[Abstract]:Aim: to study the efficacy of (HAART) in the treatment of HIV infection and HIV / AIDS (AIDS) patients and the survival time of HAART patients. Methods: 3 100 patients with HIV infection and AIDS were treated with HAART for 12 months. Plasma HIV-1 viral load was detected once a month by flow cytometry Multi SET absolute count method, CD4 T cell level and b DNA assay (detection range 1.60 log~6.10 log RNA copy / mL). The patients were observed closely. Results: after 12 months of treatment, the CD4 T cell count increased by 430 脳 10 6 / L (P0.01). The viral load decreased to a measurable level (1.70 log copy / mL) 8 months after treatment, with an average decrease of 45 log copy / mL. Conclusion: after HAART treatment, the survival rate of AIDS patients was significantly improved.
【作者单位】：广西医科大学第八附属医院传染科;广西壮族自治区贵港市疾病控制中心;
【基金】：广西贵港市科学研究与技术开发计划项目(编号:贵科学攻关1209028)
【分类号】：R512.91

【参考文献】