CIK免疫疗法治疗HBV携带者疗效观察

发布时间：2018-09-08 07:16

【摘要】：目的观察针对HBV携带者,采用CIK免疫疗法进行治疗产生的临床疗效。方法选取60例HBV携带者,随机分为两组,治疗组与对照组各30例;给予对照组常规保肝治疗,治疗组则采取常规保肝治疗+CIK免疫疗法,对HBV携带者进行治疗;观察不良反应情况,并分别于治疗前后比较两组免疫反应、细胞因子变化情况。结果治疗组出现不良反应2例,概率6.67%;治疗前HBV-DNA载量、HBV-DNA阴转情况,2组差异无统计学意义(P0.05),治疗6个月后,HBV-DNA载量下降≥2个log值,共10例,有效率为33.3%,HBV-DNA阴转共6例,有效率为20%;对照组相比,差异均有统计学意义(P0.05);比较治疗前后细胞因子变化,对照组于治疗前后无差异(P0.05),治疗组IL-2、IFN-γ升高,IL-4、IL-10水平均降低,IFN-γ/IL-10升高,均存在统计学意义(P0.05);对照组于治疗组组间依次比较,治疗后指标均出现显著差异(P0.05)。结论 CIK免疫疗法治疗HBV携带者,可有效改善Th1/Th2细胞功能,促进HBV-DNA阴转,对治疗HBV具有重要作用,值得临床推广。
[Abstract]:Objective to observe the clinical effect of CIK immunotherapy for HBV carriers. Methods 60 cases of HBV carriers were randomly divided into two groups, 30 cases in the treatment group and 30 cases in the control group. Adverse reactions were observed and the changes of immune response and cytokines were compared before and after treatment. Results there were 2 cases of adverse reactions in the treatment group, with a probability of 6.67, and there was no significant difference between the two groups before and after treatment (P0.05). After 6 months of treatment, the HBV-DNA load decreased more than 2 log values in 10 cases, the effective rate was 33. 3% HBV-DNA negative conversion in 6 cases. The effective rate was 20. Compared with the control group, the difference was statistically significant (P0.05). The changes of cytokines before and after treatment were not different in the control group (P0.05). The level of IL-4IL-10 decreased in the treatment group. There were statistical significance (P0.05); the control group in the treatment group was compared in turn, after treatment there were significant differences in the indicators (P0.05). Conclusion CIK immunotherapy for HBV carriers can effectively improve the function of Th1/Th2 cells and promote HBV-DNA negativity. It has an important role in the treatment of HBV and is worth popularizing clinically.
【作者单位】：河北省石家庄市裕强街道办事处社区卫生服务中心;河北省石家庄市第五医院;河北省赵县人民医院;
【分类号】：R512.62

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