孕期与产时启动抗病毒治疗阻断艾滋病母婴传播效果评价
发布时间：2018-09-12 04:54
【摘要】：目的对比艾滋病病毒(HIV)感染的孕产妇,经孕期与产时不同时期启动抗反转录病毒治疗(ART)后艾滋病母婴阻断的效果,探讨最大程度地减少通过母婴传播导致儿童艾滋病感染的方法。方法以30对临产时才发现HIV感染并采取紧急方案ART的孕产妇及其婴儿为观察组,以90对孕期开始应用ART的HIV感染孕产妇及其婴儿为对照组,两组均结合适宜的助产服务和人工喂养,婴儿进行HIV-1核酸和HIV抗体检测,判断HIV感染情况并进行对比分析。结果观察组有1例婴儿出生3个月死亡,有2例婴儿2次HIV-1脱氧核糖核酸检测结果均阳性,诊断婴儿HIV感染,其余27例满12~18月龄婴儿HIV抗体检测结果阴性,校正后婴儿HIV感染率为8.17%,对照组90例婴儿早期诊断和满12~18月龄HIV抗体检测结果均为阴性,婴儿HIV感染率为0,两组比较差异有统计学意义(χ~2=6.102,P0.05)。结论 HIV感染的孕产妇抗病毒治疗可以降低母婴传播的风险,孕期开始启动ART预防艾滋病母婴传播的效果明显优于产时紧急ART,结合安全分娩和人工喂养可明显降低HIV母婴传播率。
[Abstract]:Objective to compare the effect of maternal and infant blocking of HIV (HIV) infection in pregnant women during pregnancy and at different stages of labor by initiating anti-retroviral therapy after (ART). To explore ways to minimize HIV infection in children through mother-to-child transmission. Methods Thirty pairs of pregnant women and their infants who had found HIV infection at the time of labor and took emergency ART as observation group and 90 pairs of pregnant women and their infants who began to use ART as control group were used as control group. The infants were tested for HIV-1 nucleic acid and HIV antibody in combination with appropriate midwifery service and artificial feeding. The infection of HIV was judged and compared. Results in the observation group, one infant died at 3 months of birth, two infants were positive for HIV-1 DNA, the other 27 infants were diagnosed with HIV infection. The HIV antibody test results of the other 27 infants over the age of 12 ~ 18 months were negative. The corrected infantile HIV infection rate was 8.17. The early diagnosis of 90 infants in the control group and the detection of HIV antibody at the age of 12 ~ 18 months were all negative, and the infantile HIV infection rate was 0. The difference between the two groups was statistically significant (蠂 ~ (2 / 2) 6.102 (P0.05). Conclusion the antiviral therapy of HIV infection can reduce the risk of mother-to-child transmission. The effect of starting ART during pregnancy to prevent mother-to-child transmission of HIV was significantly better than that of emergency ART, combined with safe delivery and artificial feeding during labor, which could significantly reduce the rate of mother-to-child transmission of HIV.
【作者单位】： 广西艾滋病临床治疗中心南宁市第四人民医院;
【基金】：广西科学研究与技术开发计划项目(桂科攻1355005-1-3)~~
【分类号】：R512.91
，
本文编号：2237972
[Abstract]:Objective to compare the effect of maternal and infant blocking of HIV (HIV) infection in pregnant women during pregnancy and at different stages of labor by initiating anti-retroviral therapy after (ART). To explore ways to minimize HIV infection in children through mother-to-child transmission. Methods Thirty pairs of pregnant women and their infants who had found HIV infection at the time of labor and took emergency ART as observation group and 90 pairs of pregnant women and their infants who began to use ART as control group were used as control group. The infants were tested for HIV-1 nucleic acid and HIV antibody in combination with appropriate midwifery service and artificial feeding. The infection of HIV was judged and compared. Results in the observation group, one infant died at 3 months of birth, two infants were positive for HIV-1 DNA, the other 27 infants were diagnosed with HIV infection. The HIV antibody test results of the other 27 infants over the age of 12 ~ 18 months were negative. The corrected infantile HIV infection rate was 8.17. The early diagnosis of 90 infants in the control group and the detection of HIV antibody at the age of 12 ~ 18 months were all negative, and the infantile HIV infection rate was 0. The difference between the two groups was statistically significant (蠂 ~ (2 / 2) 6.102 (P0.05). Conclusion the antiviral therapy of HIV infection can reduce the risk of mother-to-child transmission. The effect of starting ART during pregnancy to prevent mother-to-child transmission of HIV was significantly better than that of emergency ART, combined with safe delivery and artificial feeding during labor, which could significantly reduce the rate of mother-to-child transmission of HIV.
【作者单位】： 广西艾滋病临床治疗中心南宁市第四人民医院;
【基金】：广西科学研究与技术开发计划项目(桂科攻1355005-1-3)~~
【分类号】：R512.91
，
本文编号：2237972
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