人类免疫缺陷病毒初始传播病毒的鉴别及其表型特征

发布时间：2018-09-12 15:14

【摘要】：人类免疫缺陷病毒(Human immunodeficiency virus type 1,HIV-1)简称艾滋病病毒,在粘膜传播过程中,病毒的遗传多样性是显著减少的。绝大多数的HIV-1粘膜感染由一个或者少数几个病毒建立并最终发展为系统感染,上述病毒称为初始传播病毒(Transmitted/founder virus,T/F virus)。通过对初始传播病毒表型特征的研究,可进一步了解病毒在新宿主体内成功复制的关键特性,为艾滋病疫苗的发展、暴露前预防及其他治疗性干预措施提供更好的策略。文章综述了初始传播病毒的发现、进化特征以及感染后初期宿主的免疫反应等,以期为深入研究初始传播病毒的特征提供理论基础。
[Abstract]:Human immunodeficiency virus (Human immunodeficiency virus type 1) is referred to as HIV. During mucosal transmission, the genetic diversity of human immunodeficiency virus (Human immunodeficiency virus type 1) is significantly reduced. The vast majority of HIV-1 mucosal infections are established by one or a few viruses and eventually develop into systemic infections, known as the initial spread virus (Transmitted/founder virus,T/F virus). Through the study of the phenotypic characteristics of the initial transmission virus, we can further understand the key characteristics of successful replication of the virus in the new host, and provide better strategies for the development of AIDS vaccine, pre-exposure prevention and other therapeutic interventions. In this paper, the discovery of the initial transmission virus, the evolutionary characteristics and the immune response of the host after infection are reviewed in order to provide a theoretical basis for the further study of the characteristics of the initial transmission virus.
【作者单位】：北京联合大学应用文理学院;中国医学科学院/北京协和医学院医药生物技术研究所;
【基金】：北京联合大学研究生创新基金(编号:12246994501) 国家基金委-加拿大国立卫生研究院研究基金课题(CIHR)合作基金(编号:81361128017)资助
【分类号】：R512.91

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