慢性乙型肝炎患者血清MCP-1水平及其与肝组织炎症、纤维化的关系

发布时间：2018-10-13 20:28

【摘要】：目的探讨单核细胞趋化蛋白-1(MCP-1)与慢性乙型肝炎(CHB)肝组织炎症和纤维化的关系。方法选择CHB患者178例(观察组)和同期健康体检者20例(对照组),观察组根据肝组织病理学检查分为组织炎症81例(炎症分级G016例、G118例、G215例、G320例、G412例)、肝纤维化97例(纤维化分期S013例、S117例、S220例、S320例、S427例),病情严重程度为轻度46例、中度59例、重度73例。采用Luminex200检测两组血清MCP-1,分析观察组血清MCP-1与肝组织炎症分级和纤维化分期的关系。结果观察组及对照组血清MCP-1水平分别为(170.4±15.6)、(74.2±11.4)pg/m L,P0.05;观察组病情轻、中、重度者血清MCP-1水平分别为(78.1±10.6)、(110.8±8.9)、(321.7±21.3)pg/m L,两两比较,P均0.05。观察组肝组织炎症分级G0~G4者血清MCP-1水平分别为(80.3±12.1)、(104.5±16.2)、(130.4±14.7)、(186.9±15.1)、(212.3±23.5)pg/m L,纤维化分期S0~S4者血清MCP-1水平分别为(90.5±18.7)、(180.3±22.1)、(224.3±32.8)、(280.9±42.8)、(335.3±48.7)pg/m L。Spearman相关分析显示,CHB患者血清MCP-1水平与肝组织炎症分级、纤维化分期均呈正相关(r分别为0.593、0.813,P均0.01)。结论 CHB患者血清MCP-1水平随病情的加重而升高,可能参与了肝组织炎症和纤维化形成。
[Abstract]:Objective to investigate the relationship between monocyte chemoattractant protein-1 (MCP-1) and liver inflammation and fibrosis in patients with chronic hepatitis B (CHB). Methods 178 patients with CHB (observation group) and 20 healthy persons (control group) were selected. According to liver histopathological examination, 81 cases of hepatic fibrosis were divided into three groups: inflammation group (G016 cases, G118 cases, G215 cases, G320 cases, G412 cases), liver fibrosis. 97 cases (fibrosis stage S013 cases, S117 cases, S220 cases, S320 cases, S427 cases), the severity of the disease was mild in 46 cases. Moderate 59 cases, severe 73 cases. The relationship between serum MCP-1 and liver inflammation grade and fibrosis stage was detected by Luminex200. Results the serum MCP-1 levels in the observation group and the control group were (170.4 卤15.6), (, 74.2 卤11.4) pg/m / L, respectively, and the serum MCP-1 levels in the patients with mild, moderate and severe disease were (78.1 卤10.6), (110.8 卤8.9), (, 321.7 卤21.3) pg/m L, respectively (P 0.05). The serum MCP-1 levels of G0~G4 patients with hepatic inflammation grade were (80.3 卤12.1), (104.5 卤16.2), (130.4 卤14.7), (186.9 卤15.1), (212.3 卤23.5) pg/m L, respectively. The serum MCP-1 levels in S0~S4 patients with fibrosis stage were (90.5 卤18.7), (180.3 卤22.1), (224.3 卤32.8), (280.9 卤42.8), (335.3 卤48.7 pg/m L.Spearman correlation analysis showed that the level of MCP-1 in patients with CHB was correlated with hepatic inflammation grade. The stage of fibrosis was positively correlated (r = 0.593 卤0.813 P 0.01). Conclusion the level of serum MCP-1 in CHB patients increases with the exacerbation of the disease, which may be involved in the formation of liver inflammation and fibrosis.
【作者单位】：首都医科大学附属北京佑安医院;
【基金】：国家国际科技合作专项项目(2012DFA30850) 北京市科技计划课题(D131100005313004、D131100005313005)
【分类号】：R512.62

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