浙江省水痘减毒活疫苗安全性研究
发布时间：2018-10-15 13:39
【摘要】：目的分析浙江省2010-2013年水痘减毒活疫苗接种后疑似预防接种异常反应(AEFI)的发生情况,评价水痘疫苗的安全性。方法通过中国疑似预防接种异常反应信息管理系统,收集2010-2013年报告的接种水痘疫苗后发生的AEFI个案,采用描述性流行病学方法进行分析评价。结果浙江省2010-2013年累计报告接种水痘疫苗后发生的AEFI个案312例,报告发生率12.10/10万剂,异常反应报告94例,报告发生率3.64/10万剂。各地区报告差异性较大,报告发生率最高的市与最低的市相差近3倍,男女性别比为1.05∶1,夏季报告较多,年龄构成比以1岁组为主。临床损害以发热、红肿、硬结等一般反应较多,异常反应则以过敏性皮疹为主,绝大部分反应发生在接种后1d内且预后较好。结论浙江省水痘疫苗安全性良好,但应重点关注急性过敏反应的监测、诊断及处置。
[Abstract]:Objective to evaluate the safety of chicken pox vaccine from 2010 to 2013 by analyzing the occurrence of suspected abnormal vaccination reaction (AEFI) after live vaccination of chickenpox vaccine in Zhejiang province. Methods the AEFI cases reported from 2010 to 2013 after vaccination were collected by China suspected vaccination abnormal response Information Management system and analyzed and evaluated by descriptive epidemiological method. Results from 2010 to 2013, 312 cases of AEFI were reported in Zhejiang province, with a reported incidence of 12.10% -100 000 doses, abnormal reaction in 94 cases, and a reported incidence of 36,400 / 100 000 doses. The difference between the highest reporting rate and the lowest city was nearly 3 times. The sex ratio of male and female was 1.05: 1. There were more reports in summer, and the age ratio was mainly in the 1-year-old group. The main clinical lesions were fever, redness and sclerosis, and the abnormal reactions were mainly allergic rash. Most of the reactions occurred within 1 day after inoculation and the prognosis was good. Conclusion chickenpox vaccine is safe in Zhejiang province, but it should focus on monitoring, diagnosis and treatment of acute allergic reaction.
【作者单位】： 浙江省疾病预防控制中心;
【基金】：浙江省医药卫生科技计划项目(2015KYA053)
【分类号】：R186.2
[Abstract]:Objective to evaluate the safety of chicken pox vaccine from 2010 to 2013 by analyzing the occurrence of suspected abnormal vaccination reaction (AEFI) after live vaccination of chickenpox vaccine in Zhejiang province. Methods the AEFI cases reported from 2010 to 2013 after vaccination were collected by China suspected vaccination abnormal response Information Management system and analyzed and evaluated by descriptive epidemiological method. Results from 2010 to 2013, 312 cases of AEFI were reported in Zhejiang province, with a reported incidence of 12.10% -100 000 doses, abnormal reaction in 94 cases, and a reported incidence of 36,400 / 100 000 doses. The difference between the highest reporting rate and the lowest city was nearly 3 times. The sex ratio of male and female was 1.05: 1. There were more reports in summer, and the age ratio was mainly in the 1-year-old group. The main clinical lesions were fever, redness and sclerosis, and the abnormal reactions were mainly allergic rash. Most of the reactions occurred within 1 day after inoculation and the prognosis was good. Conclusion chickenpox vaccine is safe in Zhejiang province, but it should focus on monitoring, diagnosis and treatment of acute allergic reaction.
【作者单位】： 浙江省疾病预防控制中心;
【基金】：浙江省医药卫生科技计划项目(2015KYA053)
【分类号】：R186.2
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