蓬莱市健康人群新布尼亚病毒感染的血清学调查
发布时间：2018-10-17 19:08
【摘要】：目的了解蓬莱市健康人群发热伴血小板减少综合征布尼亚病毒(SFTSV)感染情况,并分析其分布规律及流行因素,为控制疫情提供理论依据。方法采用多阶段整群随机抽样方法抽取健康人群1 525人,采集其血液标本并分离血清,采用间接酶联免疫吸附实验(ELISA)检测人群中新布尼亚病毒特异性Ig G抗体,并采用统计学方法对不同年龄组人群、不同时间采集人群血清抗体阳性率进行比较。结果 1 525人份血清中,新布尼亚病毒特异性Ig G抗体阳性138份,阳性率为9.05%,男性人群抗体阳性率为9.28%(61/657),女性抗体阳性率为8.87%(77/868),两者差异无统计学意义(χ2=0.078,P0.05)。各年龄组人群均有感染,以61~70岁年龄组人群新布尼亚病毒抗体阳性率最高,各年龄组人群抗体阳性率组间的差异具有统计学意义(χ2=46.86,P0.05),农民抗体阳性率明显高于学生(χ2=6.45,P0.05),流行后期人群抗体阳性率高于流行期人群抗体水平(χ2=9.36,P0.01)。结论蓬莱市健康人群中发热伴血小板减少综合征布尼亚病毒抗体阳性率较高,提示大多数SFTSV病毒感染后宿主体内产生的抗体可能会持续较长时间,为我们了解疾病的发生、发展规律提供了基础的理论数据。该病毒在蓬莱市流行强度较强,应引起高度重视。
[Abstract]:Objective to investigate the prevalence of (SFTSV) infection of fever associated with thrombocytopenia syndrome (SFTSV) in a healthy population of Penglai City, and to analyze its distribution and epidemic factors so as to provide a theoretical basis for the control of the epidemic situation. Methods Serum samples were collected from 1 525 healthy people by multistage cluster random sampling. The specific Ig G antibody of Neobania virus was detected by indirect enzyme-linked immunosorbent assay (ELISA). The positive rates of serum antibodies in different age groups and different time groups were compared by statistical method. Results among 1 525 serum samples, 138 samples were positive for Ig G antibody, the positive rate was 9.05. The positive rate of antibody was 9.28% (61 / 657) in male and 8.87% (77 / 868) in female. There was no significant difference between the two groups (蠂 2 / 0.078 P 0.05). The positive rate of new Bunia virus antibody was the highest in the 61- 70 age group. The positive rate of antibody in farmers was significantly higher than that in students (蠂 2 + 6.45%, P < 0.05), and the positive rate of antibody in the later period of epidemic was higher than that in the epidemic period (蠂 2 9. 36% P 0.01). The positive rate of antibody in different age groups was statistically significant (蠂 2 + 46.86% P < 0.05), and the positive rate of peasant antibody was significantly higher than that of students (蠂 2 + 6.45% P 0.05). Conclusion the positive rate of antibodies against Bunia virus in patients with fever and thrombocytopenia syndrome is higher in the healthy population of Penglai, suggesting that the antibodies produced in the host may last for a long time after the infection of SFTSV virus, which is helpful for us to understand the occurrence of the disease. The law of development provides basic theoretical data. The epidemic intensity of the virus in Penglai City is relatively strong, which should be attached great importance to.
【作者单位】： 蓬莱市疾病预防控制中心;山东省疾病预防控制中心;
【基金】：国家自然科学青年基金项目(81102171) 山东省医药卫生科技发展计划(2011HZ055) 山东省科学技术发展计划(2012GHZ30031)
【分类号】：R510
[Abstract]:Objective to investigate the prevalence of (SFTSV) infection of fever associated with thrombocytopenia syndrome (SFTSV) in a healthy population of Penglai City, and to analyze its distribution and epidemic factors so as to provide a theoretical basis for the control of the epidemic situation. Methods Serum samples were collected from 1 525 healthy people by multistage cluster random sampling. The specific Ig G antibody of Neobania virus was detected by indirect enzyme-linked immunosorbent assay (ELISA). The positive rates of serum antibodies in different age groups and different time groups were compared by statistical method. Results among 1 525 serum samples, 138 samples were positive for Ig G antibody, the positive rate was 9.05. The positive rate of antibody was 9.28% (61 / 657) in male and 8.87% (77 / 868) in female. There was no significant difference between the two groups (蠂 2 / 0.078 P 0.05). The positive rate of new Bunia virus antibody was the highest in the 61- 70 age group. The positive rate of antibody in farmers was significantly higher than that in students (蠂 2 + 6.45%, P < 0.05), and the positive rate of antibody in the later period of epidemic was higher than that in the epidemic period (蠂 2 9. 36% P 0.01). The positive rate of antibody in different age groups was statistically significant (蠂 2 + 46.86% P < 0.05), and the positive rate of peasant antibody was significantly higher than that of students (蠂 2 + 6.45% P 0.05). Conclusion the positive rate of antibodies against Bunia virus in patients with fever and thrombocytopenia syndrome is higher in the healthy population of Penglai, suggesting that the antibodies produced in the host may last for a long time after the infection of SFTSV virus, which is helpful for us to understand the occurrence of the disease. The law of development provides basic theoretical data. The epidemic intensity of the virus in Penglai City is relatively strong, which should be attached great importance to.
【作者单位】： 蓬莱市疾病预防控制中心;山东省疾病预防控制中心;
【基金】：国家自然科学青年基金项目(81102171) 山东省医药卫生科技发展计划(2011HZ055) 山东省科学技术发展计划(2012GHZ30031)
【分类号】：R510
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