76例经艾滋病母婴阻断治疗的HIV阳性孕妇产后的临床体征和免疫功能变化

发布时间：2018-10-19 11:17

【摘要】：目的分析经艾滋病母婴阻断治疗(PMTCT)艾滋病病毒(HIV)阳性孕产妇,产后的临床体征、血色素、肝功能及免疫功能变化情况,为进一步指导艾滋病母婴阻断工作提供科学治疗依据。方法对广西2004-2010年76例经PMTCT的HIV阳性孕产妇,在产后2年定期随访,其中31例产后继续接受高效抗反转录病毒治疗(HAART),45例产后停止HAART,对比分析她们的临床体征及实验室检测的血色素(HGB)、中性粒细胞(NC)、肝功能(ALT)和免疫功能[CD+4T淋巴细胞(简称CD4细胞)]的变化。结果在31例产后服药的孕产妇中,4例在产后平均2年后出现司坦夫定(D4T)药物关联的体型改变,2例自产后1年内出现严重的齐多夫定(AZT)贫血;45例产后停药者未出现相关临床体征。31例产后服药的孕产妇,在产后2年内CD4细胞计数比PMTCT前有显著性提高。45例产后停药的孕产妇,其CD4细胞计数在产后1年以后有显著性下降。31例产后服药和45例产后停止服药的孕产妇,产后2年定期随访HGB,NC,ALT均无显著性变化。结论广西孕产妇在服用AZT药后,对部分孕产妇血色素影响明显,部分孕产妇服用D4T治疗2年后有脂肪转移严重不良反应。艾滋病母婴阻断后停药的孕产妇CD4细胞水平下降较快。在艾滋病母婴阻断后停药或继续服药的孕产妇,其产后2年内的HGB、NC、ALT影响不明显。
[Abstract]:Objective to analyze the changes of clinical signs, hemoglobin, liver function and immune function in pregnant and parturient women with (PMTCT) HIV (HIV) positive treatment by maternal and infant block, and to provide scientific treatment basis for further guiding the work of maternal and infant AIDS blocking. Methods 76 cases of HIV positive pregnant and lying-in women with PMTCT in Guangxi from 2004 to 2010 were followed up regularly in 2 years postpartum. Among them, 31 cases continued to receive highly effective antiretrovirals after delivery (HAART), 45 cases stopped postpartum HAART, comparative analysis of their clinical signs and laboratory detection of hemoglobin (HGB), neutrophil (NC), liver function (ALT) and immune function [CD 4T lymphocyte] (CD4 cells). Results among 31 postpartum drug taking pregnant women, 4 cases had D4T associated body changes after postpartum on average 2 years, 2 cases had severe zidovudine (AZT) anemia within 1 year after delivery, and 45 cases of postpartum drug withdrawal did not appear. Related clinical signs. 31 pregnant and parturient women taking drugs after delivery, The count of CD4 cells in postpartum women was significantly higher than that before PMTCT. The count of CD4 cells in 45 pregnant women who stopped taking drugs after postpartum was significantly decreased after 1 year postpartum. There were 31 cases of postpartum drug taking and 45 cases of postpartum women who stopped taking drugs. There was no significant change in HGB,NC,ALT during 2 years postpartum follow-up. Conclusion the hemoglobin of some pregnant and lying-in women in Guangxi was significantly affected after taking AZT, and some pregnant and lying-in women had serious adverse reactions of fat metastasis after 2 years of treatment with D4T. The CD4 cell level of pregnant and parturient who stopped taking drugs after blocking the mother and infant of AIDS decreased rapidly. The effect of HGB,NC,ALT was not obvious in the pregnant women who stopped taking drugs or continued to take drugs after the interruption of mother and child AIDS within 2 years postpartum.
【作者单位】：广西壮族自治区疾病预防控制中心;
【分类号】：R512.91

【参考文献】