12例气管真菌病的临床分析
发布时间:2018-10-21 14:10
【摘要】:目的:探讨气管真菌病的临床特点,提高对该病的认识,尽早诊断,及时治疗,以获得更好的临床疗效,改善预后。方法:回顾性分析2012年3月至2016年3月期间于山东省立医院住院并临床确诊的12例气管真菌病患者的病历资料,对其年龄、性别、临床特点、病原学、诊断和治疗方法及转归进行分析。结果:12例气管真菌病患者年龄14岁-74岁,中位年龄59岁,年龄≥60岁者5例(5/12),其中男性4例,女性8例,男女比例1:2。12例患者中,曲霉菌3例,其余患者未明确具体病原菌类型;临床症状无特异性,以发热、咳嗽咳痰为主,其次为痰中带血;大多有基础疾病,如肿瘤、结核、糖尿病、COPD等致免疫低下疾病;危险因素主要有应用糖皮质激素、长期应用广谱抗生素、放化疗等;研究的12例气管真菌病均由病理证实而确诊;镜下表现多见黄白色或暗褐色新生物附着;7例患者经治疗后取得较好的临床疗效,2例患者因发生大咯血抢救无效死亡,3例患者未行抗真菌治疗,随访未见真菌感染的证据,考虑为气管内定植菌。结论:局限于气管的真菌病较少见,临床表现亦无特异性,容易漏诊及误诊。大多有基础疾病,对可疑病例进行多方面的检查,根据患者的自身情况及疾病特点,合理采用抗真菌药物是治疗的关键。有些真菌如曲霉菌、毛霉菌可侵犯血管,导致致命性大咯血,需提高警惕。无症状患者未应用抗真菌药物,随访未发展成为侵袭性真菌感染,考虑为气管内定植菌,但需定期随访。
[Abstract]:Objective: to investigate the clinical features of tracheobronchomycosis, to improve the understanding of the disease, to diagnose and treat it as soon as possible, to obtain better clinical effect and to improve the prognosis. Methods: the medical records of 12 cases of tracheobronchomycosis hospitalized in Shandong Provincial Hospital from March 2012 to March 2016 were retrospectively analyzed. Diagnosis, treatment and outcome were analyzed. Results: the age of 12 patients with tracheobronchomycosis was 14 to 74 years old, the median age was 59 years old, the age 鈮,
本文编号:2285334
[Abstract]:Objective: to investigate the clinical features of tracheobronchomycosis, to improve the understanding of the disease, to diagnose and treat it as soon as possible, to obtain better clinical effect and to improve the prognosis. Methods: the medical records of 12 cases of tracheobronchomycosis hospitalized in Shandong Provincial Hospital from March 2012 to March 2016 were retrospectively analyzed. Diagnosis, treatment and outcome were analyzed. Results: the age of 12 patients with tracheobronchomycosis was 14 to 74 years old, the median age was 59 years old, the age 鈮,
本文编号:2285334
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