可溶性人白细胞抗原G在肺结核患者中的表达及临床意义

发布时间：2018-10-29 15:56

【摘要】：目的观察初治涂阳肺结核患者血清可溶性人白细胞抗原G(s HLA-G)水平变化,并探讨其临床意义。方法该院60例首诊涂阳肺结核患者,根据病变累及范围分为广泛组21例与不广泛组39例。检测血清s HLA-G、T淋巴细胞亚群(CD_4~+、CD_8~+、CD_4~+/CD_8~+)水平,对比两组水平变化。结果治疗后两组血清s HLA-G、CD_8~+水平明显下降,CD_4~+和CD_4~+/CD_8~+水平明显上升,广泛组血清s HLA-G、CD_8~+水平明显高于不广泛组,CD_4~+和CD_4~+/CD_8~+水平低于不广泛组。结论血清s HLA-G可能对CD_4~+、CD_8~+、CD_4~+/CD_8~+等T淋巴细胞亚群具有调节作用,需进一步探究其作用机制。
[Abstract]:Objective to observe the changes of serum soluble human leukocyte antigen (G (s HLA-G) in patients with smear positive pulmonary tuberculosis and to explore its clinical significance. Methods 60 cases of smear positive pulmonary tuberculosis were divided into extensive group (21 cases) and non-extensive group (39 cases) according to the extent of involvement. The levels of serum s HLA-G,T lymphocyte subsets (CD_4~, CD_8~, CD_4~ / CD_8~) were measured and compared between the two groups. Results after treatment, the levels of serum s HLA-G,CD_8~, CD_4~ and CD_4~ / CD_8~ in the two groups were significantly decreased, and the levels of serum s HLA-G,CD_8~ in the extensive group were significantly higher than those in the non-extensive group. The levels of CD_4~ and CD_4~ / CD_8~ were lower than those of the non-extensive group. Conclusion Serum s HLA-G may regulate T lymphocyte subsets such as CD_4~, CD_8~, CD_4~ / CD_8~ and so on.
【作者单位】：杭州师范大学附属医院结核科;
【基金】：杭州市卫生科技计划项目(2014A20)
【分类号】：R521

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