侵袭性肺真菌感染的临床分析

发布时间：2018-10-29 20:56

【摘要】：目的对病理确诊的侵袭性肺真菌感染(IPFI)病例进行临床分析,了解IPFI患者的危险因素、临床及影像特点,加深对IPFI的认识,提高临床诊治水平。方法回顾分析1997-2014年医院病理确诊的IPFI患者32例,对资料记载的相关危险因素、临床表现、病原学、影像学表现及病理结果,比较继发性和原发性IPFI的临床特点。结果 IPFI临床表现不特异,继发性IPFI年龄大,更多表现为发热、咳嗽和/或咳痰、呼吸困难;原发性IPFI影像学表现以结节或肿块为主;32例确诊IPFI患者,25例继发性IPFI患者中13例为曲霉菌感染;7例原发性IPFI中6例隐球菌感染;8例死亡病例均为继发性IPFI。结论 IPFI以曲霉菌感染为主,临床表现及影像学不特异;继发性IPFI患者年龄大、病死率高,原发性IPFI临床症状少,需尽早行侵袭性治疗协助诊断。
[Abstract]:Objective to investigate the risk factors, clinical and imaging features of invasive pulmonary fungal infection (IPFI) in patients with IPFI, and to deepen the understanding of IPFI and improve the level of clinical diagnosis and treatment. Methods Thirty-two patients with IPFI diagnosed by pathology from 1997 to 2014 were retrospectively analyzed. The clinical features of secondary and primary IPFI were compared with those of clinical risk factors, clinical manifestations, etiology, imaging findings and pathological findings. Results the clinical manifestations of IPFI were not specific, the secondary IPFI was older, and the main manifestations were fever, cough and / or expectoration, dyspnea, nodule or mass in primary IPFI. Of 32 confirmed IPFI patients, 13 of 25 secondary IPFI patients were aspergillus infection, 6 of 7 primary IPFI patients were Cryptococcus infection, and 8 died of secondary IPFI.. Conclusion IPFI is mainly aspergillus infection, its clinical manifestation and imaging are not specific, the patients with secondary IPFI are old, mortality is high, and the clinical symptoms of primary IPFI are few, so it is necessary to carry out invasive therapy to assist in diagnosis as soon as possible.
【作者单位】：北京医院国家老年医学中心呼吸与危重症医学科;北京医院国家老年医学中心病理科;
【基金】：国家科技重大专项基金资助项目[重大传染病防治专项(2015ZX)] 卫计委公益性行业科研专项基金资助项目(201502003)
【分类号】：R519

【相似文献】