还原型谷胱甘肽治疗抗结核药所致肝损害

发布时间：2018-10-29 22:22

【摘要】：目的探讨还原型谷胱甘肽对抗结核药所致轻、中度肝损伤的临床疗效,方法抗结核药所致肝损伤病人200例,分成2组,治疗组112人,不停用抗结核药物,加用还原型谷胱甘肽粉针1.2g,静脉滴注,每日1次,连用4周,对照组88例,停用抗结核药且不用还原型谷胱甘肽,两组均采用基础治疗(维生素C注射液、肌苷片),结果两组临床总有效率分别为94.67%和68.95%(P0.01),治疗组中ALT、AST、Y-GT、ALP和TBIL治疗前后的测定值差异有显著性(P0.05),分别为ALT(203±60)与(52±18u·L~(-1);AST(187±46)与(67±22)u·L~(-1);r-GT(132±27)与(71±32)u·L~(-1);ALP(164±42)与(118±25)u·L~(-1);TBIL(82±36)与(31±14)umol·L~(-1)。治疗组各项肝功能指标明显优于对照组(P0.01)。结论还原型谷胱甘肽对抗结核药所致的轻、中度肝损伤有明显治疗作用。
[Abstract]:Objective to investigate the clinical efficacy of reduced glutathione in the treatment of mild and moderate liver injury induced by tuberculosis drugs. Methods 200 patients with liver injury caused by antituberculous drugs were divided into two groups: treatment group (n = 112) and control group (n = 112). The patients in the control group were treated with reduced glutathione powder needle 1.2 g, intravenous drip once a day for 4 weeks. 88 patients in the control group were treated with basic therapy (Vitamin C injection, inosine tablet) without reducing glutathione. Results the total clinical effective rates of the two groups were 94.67% and 68.95% (P0.01) respectively. There was significant difference in the values of ALT,AST,Y-GT,ALP and TBIL before and after treatment (P0.05). ALT (203 卤60) and (52 卤18u L ~ (-1); AST (187 卤46) and (67 卤22) u L ~ (-1); r-GT (132 卤27) and (71 卤32) u L ~ (-1); ALP (164 卤42 and (118 卤25) u L ~ (-1); TBIL (82 卤36 and (31 卤14) umol L ~ (-1). The indexes of liver function in the treatment group were obviously superior to those in the control group (P 0.01). Conclusion reduced glutathione has obvious therapeutic effect on mild and moderate liver injury induced by tuberculosis drugs.
【作者单位】：吉林省白山市妇幼保健院;
【分类号】：R52;R575

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