HLA-DQ基因遗传变异与丙型肝炎病毒感染转归的相关性研究

发布时间：2018-11-05 09:57

【摘要】：目的探讨遗人类白细胞抗原(human leukocyte antigen,HLA)DQ基因多态性与丙型肝炎感染转归的关联。方法应用Taq Man探针方法检测339例丙型肝炎病毒(hepatitis C virus,HCV)持续感染者,262例HCV自限感染者和942例健康对照者HLA-DQ基因rs2856718和rs7453920位点的基因多态性,比较不同基因型与丙型肝炎病毒感染转归的关系。结果采用多因素Logistic回归分析,结果显示rs2856718位点杂合基因型AG在感染组中的频率均低于对照组(调整OR=0.73,95%CI:0.56~0.94);另外,rs7453920 AA基因型可增加个体对HCV的易感性(调整OR=1.75,95%CI:1.01~3.03)。结果显示,与AG单倍型相比,携带AA单倍型的个体可增加丙型肝炎易感性(调整OR=1.67,95%CI:1.11~2.52)。分层分析结果发现,在男性人群中,rs2856718位点的杂合基因型AG在感染组中的频率低于对照组(调整OR=0.68,95%CI:0.51~0.93);在45~60岁人群中,rs7453920位点突变纯合基因型GG在感染组中的频率高于对照组(调整OR=2.35,95%CI:1.11~4.98)。结论 HLA-DQ基因多态性与丙型肝炎病毒感染转归存在关联。
[Abstract]:Objective to investigate the association between polymorphisms of human leukocyte antigen (human leukocyte antigen,HLA) DQ gene and the outcome of hepatitis C infection. Methods HLA-DQ gene rs2856718 and rs7453920 loci were detected by Taq Man probe method in 339 patients with hepatitis C virus (hepatitis C virus,HCV, 262 patients with HCV self-limited infection and 942 healthy controls. To compare the relationship between different genotypes and the outcome of hepatitis C virus infection. Results the multivariate Logistic regression analysis showed that the frequency of rs2856718 heterozygous genotype AG in the infected group was lower than that in the control group (adjusted OR=0.73,95%CI:0.56~0.94). In addition, rs7453920 AA genotype can increase individual susceptibility to HCV (adjust OR=1.75,95%CI:1.01~3.03). The results showed that individuals with AA haplotypes increased their susceptibility to hepatitis C (adjusted OR=1.67,95%CI:1.11~2.52) compared with AG haplotypes. The results of stratification analysis showed that the frequency of heterozygous AG at rs2856718 locus in infected group was lower than that in control group (adjusted OR=0.68,95%CI:0.51~0.93). The frequency of homozygous genotype GG of rs7453920 locus mutation was higher in the infected group than in the control group (adjusted OR=2.35,95%CI:1.11~4.98). Conclusion HLA-DQ gene polymorphism is associated with the outcome of hepatitis C virus infection.
【作者单位】：江南大学无锡医学院基础医学实验中心;南京军区军事医学研究所流行病与微生物研究所;
【基金】：国家自然科学基金(81273146)
【分类号】：R512.63

【相似文献】