不同临床类型慢乙肝患者外周血T细胞亚群变化及意义

发布时间：2018-11-16 10:20

【摘要】：目的通过分析慢性乙型肝炎、乙肝肝硬化、慢性肝衰竭患者外周血T淋巴细胞亚群百分比变化,探讨T细胞亚群变化与不同临床类型慢乙肝患者病程之间的关系。方法采用流式细胞仪技术,检测36例慢性乙型肝炎患者、55例乙肝肝硬化患者、20例慢性肝衰竭患者外周血CD3+T、CD4+T、CD8+T淋巴细胞百分比及CD4+T/CD8+T细胞百分比比值。结果(1)CD3+T、CD8+T细胞百分比在慢性乙型肝炎组、乙肝肝硬化组、慢性肝衰竭组三组间进行比较,差异具有统计学意义(P0.05)。且CD3+T、CD8+T细胞百分比在三组间的差异存在一定规律,随着疾病进展,CD3+T、CD8+T细胞百分比呈逐渐下降趋势,即:慢性乙型肝炎组乙肝肝硬化组慢性肝衰竭组。(2)CD4+T细胞百分比、CD4+T/CD8+T细胞百分比比值在慢性乙型肝炎组、乙肝肝硬化组、慢性肝衰竭组三组间进行比较,差异无统计学意义(P0.05)。(3)CD3+T、CD8+T细胞百分比分别在三组之间行两两比较,研究结果显示,慢性乙型肝炎组与乙肝肝硬化组比较差异无统计学意义(P0.05)。慢性肝衰竭组与慢性乙型肝炎组比较,差异有统计学意义(P0.05)。慢性肝衰竭组与乙肝肝硬化组比较,差异有统计学意义(P0.05)。结论不同临床类型慢乙肝患者,随着疾病进展,外周血T淋巴细胞亚群百分比逐渐下降,其中慢性肝衰竭患者T淋巴细胞下降尤为明显。监测外周血T淋巴细胞亚群变化,可作为判定病情发展阶段及评估预后的重要指标。
[Abstract]:Objective to analyze the percentage of T lymphocyte subsets in peripheral blood of patients with chronic hepatitis B, liver cirrhosis and chronic liver failure, and to explore the relationship between the changes of T lymphocyte subsets and the course of disease in patients with chronic hepatitis B. Methods flow cytometry was used to detect the percentage of CD3 T 4 T T cell and the percentage of CD4 T/CD8 T cells in peripheral blood of 36 patients with chronic hepatitis B, 55 patients with liver cirrhosis and 20 patients with chronic liver failure. Results (1) the percentage of CD3 T 8 T cells in chronic hepatitis B group, hepatitis B cirrhosis group and chronic liver failure group were compared, the difference was statistically significant (P0.05). The percentage of CD8 T cells in CD3 Tnn was different among the three groups. With the disease progression, the percentage of CD8 T cells in CD3 Tnr decreased gradually, and the percentage of CD8 T cells decreased gradually with the development of the disease. (2) the percentage of CD4 T cells and the ratio of CD4 T/CD8 T cells in chronic hepatitis B group, hepatitis B cirrhosis group and chronic liver failure group were compared among three groups. There was no significant difference (P0.05). (3) in the percentage of CD3 T 8 T cells between the three groups. The results showed that there was no significant difference between chronic hepatitis B group and hepatitis B cirrhosis group (P0.05). Chronic liver failure group and chronic hepatitis B group, the difference was statistically significant (P0.05). Chronic liver failure group and liver cirrhosis group, the difference was statistically significant (P0.05). Conclusion the percentage of T lymphocyte subsets in peripheral blood of patients with different clinical types of chronic hepatitis B decreased with the progression of the disease, especially in patients with chronic liver failure. Monitoring the changes of T lymphocyte subsets in peripheral blood can be used as an important index to judge the stage of disease development and to evaluate the prognosis.
【学位授予单位】：宁夏医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R512.62

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