HIV感染者和AIDS患者外周血T淋巴细胞活化亚群与病毒载量的相关性

发布时间：2018-11-24 20:49

【摘要】：目的探讨HIV感染者和AIDS患者外周血T淋巴细胞活化亚群与病毒载量相关性。方法 2012年6-8月选择河南省某AIDS高发地区HIV感染者322例和AIDS患者87例为研究对象,分别采用流式细胞仪和全自动病毒载量仪检测HIV感染者和AIDS患者外周血T淋巴细胞及其活化亚群和血浆病毒载量,根据病毒载量水平将研究对象分为Ⅰ-Ⅳ组。结果HIV感染者与AIDS患者CD_3~+T细胞相对值、CD_(28)~+/CD_4~+比较,差异无统计学意义(P0.05)。HIV感染者淋巴细胞绝对值和相对值、CD_3~+T细胞绝对值、CD_3~+CD_8~+T细胞绝对值、CD_3~+CD_4~+T细胞绝对值和相对值、CD_3~+CD_4~+CD_8~+T细胞绝对值均高于AIDS患者,CD_3~+CD_8~+T细胞相对值低于AIDS患者,辅助性T细胞与抑制性T细胞比值(H/S)、CD_(28)~+/CD_8~+高于AIDS患者,CD_(38)~+/CD_8~+低于AIDS患者,差异均有统计学意义(P0.05)。各组淋巴细胞绝对值和相对值、CD_3~+T细胞相对值、CD_3~+CD_8~+T细胞相对值、CD_3~+CD_4~+T细胞绝对值和相对值及H/S、CD_(28)~+/CD_4~+、CD_(28)~+/CD_8~+、CD_(38)~+/CD_8~+比较,差异均有统计学意义(P0.05)。CD_3~+T细胞相对值、CD_3~+CD_8~+T细胞相对值及CD_(38)~+/CD_8~+与病毒载量水平呈正相关(r_s=0.128、0.291、0.409,P0.05);CD_3~+CD_4~+T细胞绝对值和相对值、H/S、CD_(28)~+/CD_4~+、CD_(28)~+/CD_8~+与病毒载量水平呈负相关(r_s=-0.246、-0.318、-0.297、-0.184、-0.204,P0.05)。结论 HIV感染者和AIDS患者T淋巴细胞活化过程发生变化;随着病毒载量水平变化,HIV感染者和AIDS患者的T淋巴细胞活化亚群水平也不同。
[Abstract]:Objective to investigate the correlation between T lymphocyte activation subsets and viral load in HIV infected patients and AIDS patients. Methods 322 cases of HIV infection and 87 cases of AIDS in a high incidence area of AIDS in Henan Province were selected from June to August 2012. The peripheral blood T lymphocytes and their activated subsets and plasma viral load of HIV infected patients and AIDS patients were detected by flow cytometry and automatic virus loading instrument, respectively. According to the viral load level, the subjects were divided into group 鈪，

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