CXC趋化因子配体10与病毒性肝炎研究进展

发布时间：2018-12-09 08:39

【摘要】：在病毒性肝炎疾病进展的过程之中,淋巴细胞向受病毒感染的肝组织迁移及侵润,对抗病毒免疫应答和炎症反应的发生起着至关重要的作用,但对其机理的研究尚未取得令人满意的答案。近几年来,CXC趋化因子配体(CXC chemokine ligand,CXCL)10是目前研究较多的一个细胞因子,其受体是CXCR3,两者之间的相互作用已成为病毒性肝炎的发生及发展机制的重要突破点。本文就CXCL10在病毒性肝炎中的意义及对抗病毒疗效评估的相关研究进展作一综述。CXCL10,又名干扰素γ诱导蛋白10,属于CXC亚家族中的ELR—趋化因子,CXCL10主要与趋化因子受体CXCR3结合而发挥作用,其主要作用包括促进细胞趋化、诱导细胞凋亡、调节细胞生长和增殖及调节血管生成等;多项研究显示,慢性HBV、HCV感染者血清及肝组织CXCL10表达水平增高,且随着肝脏炎症及纤维化程度的加重,CXCL10水平也随之增加,提示了CXCL10在肝脏病理损伤过程中可能发挥了重要的作用;在应用抗HBV、HCV药物治疗后,血清CXCL10水平逐渐下降,提示CXCL10在病毒清除过程中可能发挥了重要作用,并发现血清CXCL10基线水平及治疗过程中CXCL10的下降幅度可能有效预测抗病毒疗效。但CXCL10参与病毒性肝炎病理过程的机制及在抗病毒治疗过程中的作用机制尚不清楚,仍需要进一步研究。
[Abstract]:In the progress of viral hepatitis disease, lymphocyte migration and infiltration into the infected liver tissue, anti-viral immune response and inflammatory response plays a vital role. However, the study of its mechanism has not yet obtained a satisfactory answer. In recent years, CXC chemokine ligand (CXC chemokine ligand,CXCL) 10 is one of the most widely studied cytokines. Its receptor is an important breakthrough point of the mechanism of occurrence and development of viral hepatitis. This article reviews the significance of CXCL10 in viral hepatitis and the related research progress in the evaluation of antiviral efficacy. CXCL10, also known as interferon 纬 inducible protein 10, belongs to the ELR- chemokine in the CXC subfamily. CXCL10 mainly binds to chemokine receptor CXCR3. Its main functions include promoting cell chemotaxis, inducing apoptosis, regulating cell growth and proliferation, and regulating angiogenesis. A number of studies have shown that the expression of CXCL10 in serum and liver tissues of chronic HBV,HCV infected patients increased, and with the severity of liver inflammation and fibrosis, the level of CXCL10 also increased. The results suggest that CXCL10 may play an important role in the process of liver pathological injury. The level of serum CXCL10 decreased gradually after treatment with antiviral HBV,HCV drugs, suggesting that CXCL10 may play an important role in the process of virus clearance. It was found that the baseline level of serum CXCL10 and the decrease of CXCL10 in the course of treatment might be effective in predicting the antiviral effect. However, the mechanism of CXCL10 involved in the pathological process of viral hepatitis and its role in antiviral therapy are still unclear, and need to be further studied.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R512.6

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