高效抗逆转录病毒治疗对HIV感染者口腔疱疹性损害的影响

发布时间：2018-12-13 19:43

【摘要】：目的初步探明高效抗逆转录病毒治疗(Highly Active Anti-Retroviral Therapy,HAART)对云南地区人类免疫缺陷病毒(Human Immunodeficiency Virus,HIV)感染者人类疱疹病毒(Human Herpes Virus,HHV)相关口腔损害发病情况的影响。方法对2009年2月-2012年8月到云南省昆明市第三人民医院感染一科接受HAART治疗的HIV感染者HHV相关口腔损害的发病情况进行调查,采用SPSS13.0建立数据库并进行相关指标的统计分析。结果 (1)使用HAART与未使用HAART患者口腔HHV相关损害观察对比,两组之间口腔单纯疱疹(HS)、带状疱疹(HZ)、口腔毛状白斑(OHL)、口腔溃疡(OU)和卡波西肉瘤(KS)的发病率分别为0.31%、0.76%、0.46%、3.80%、0.76%和10.79%、0.71%、9.07%、9.27%、0.50%,表明HAART的使用让患者大多数口腔疱疹病毒的机会性感染有所下降;(2)HAART治疗失败后口腔单纯疱疹、口腔毛状白斑和口腔溃疡的发病率上升,表明HAART降低了HHV相关口腔损害发病;另外,口腔毛状白斑在HIV感染早期诊断及抗病毒治疗成败方面也有参考价值。结论人类疱疹病毒相关的口腔损害在云南地区HIV感染患者中的发病率较高,HAART的使用可以有效地降低HHV相关的口腔损害。这不仅能提高HIV患者的生活质量,同时HHV相关的口腔损害也为HIV感染早期诊断及抗病毒治疗的成败提供重要的参考依据。
[Abstract]:Objective to investigate the effect of highly effective antiretroviral therapy (Highly Active Anti-Retroviral Therapy,HAART) on the incidence of oral lesions associated with human herpesvirus (Human Herpes Virus,HHV) in people infected with human immunodeficiency virus (Human Immunodeficiency Virus,HIV) in Yunnan province. Methods from February 2009 to August 2012, we investigated the incidence of HHV related oral lesions among HIV infected patients who received HAART treatment from the third people's Hospital infection Department of Kunming, Yunnan Province, from February 2009 to August 2012. Use SPSS13.0 to establish database and statistical analysis of related indicators. Results (1) the oral HHV related lesions in patients with HAART and those without HAART were observed and compared. Between the two groups, (HS), herpes zoster, (HZ), oral hair leukoplakia and (OHL), were observed between the two groups. The incidence of oral ulcer (OU) and Kaposi sarcoma (KS) were 0.31 and 0.76, 0.46 and 0.76%, 0.76% and 0.79%, 0.71% and 0.50%, respectively. The results showed that the use of HAART reduced the opportunistic infection of oral herpes virus in most patients. (2) the incidence of oral herpes simplex, oral hair leukoplakia and oral ulcer increased after the failure of HAART treatment, indicating that HAART decreased the incidence of HHV related oral lesions; In addition, oral hair-like leukoplakia also has reference value in early diagnosis of HIV infection and success or failure of anti-viral therapy. Conclusion the incidence of human herpesvirus-related oral lesions is higher in HIV infection patients in Yunnan area. The use of HAART can effectively reduce the HHV related oral lesions. It can not only improve the quality of life of HIV patients, but also provide an important reference for the early diagnosis of HIV infection and the success or failure of antiviral therapy.
【作者单位】：昆明医科大学附属延安医院;昆明市延安医院口腔科;昆明市第三人民医院感染一科;
【基金】：国家自然科学基金资助项目(30860315,81160135) 云南省应用基础研究项目(2008ZC146M)
【分类号】：R512.91

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