适应性策略:人类致病真菌新生隐球菌的“杀手锏”

发布时间：2018-12-16 12:35

【摘要】：绝大多数引发人体系统感染的致病真菌来自于环境,这些环境来源的真菌往往是条件致病菌,其毒力衍生于它们独特的生境适应策略。新生隐球菌是进化最为成功的环境真菌之一,在自然界中的分布极为广泛。而作为人类致病菌,新生隐球菌能够引发致命的隐球菌病和真菌脑膜炎,据统计全球每年由于隐球菌病死亡的人数超过60万人。近几年的研究表明,新生隐球菌的环境适应策略对其条件致病性至关重要。细胞细胞交流、细胞形态转换和细胞异质性等重要环境适应行为在协调新生隐球菌的致病性方面都扮演了重要的角色。文章从致病菌?自然栖居环境?人类宿主三方的关系解析了新生隐球菌环境适应策略影响毒力的机制及相关进化动机,并对其潜在的研究前景和临床应用提出了一些思考。
[Abstract]:Most of the pathogenic fungi that cause human systemic infection come from the environment. These fungi are conditioned pathogens and their virulence is derived from their unique habitat adaptation strategies. Cryptococcus neoformans (Cryptococcus neoformans) is one of the most successful evolutional environmental fungi and is widely distributed in nature. As a human pathogen Cryptococcus neoformans can cause fatal Cryptococcosis and fungal meningitis. According to statistics more than 600000 people die of Cryptococcus neoformans every year in the world. Recent studies have shown that environmental adaptation strategies of Cryptococcus neoformans are critical to their conditioned pathogenicity. Some important environmental adaptation behaviors, such as cell communication, cell morphologic transformation and cell heterogeneity, play an important role in coordinating the pathogenicity of Cryptococcus neoformans. Article from pathogenic bacteria? Natural habitat? The relationship between human hosts and the environmental adaptation strategies of Cryptococcus neoformans has explained the mechanism of its virulence and related evolutionary motivations. The potential research prospects and clinical applications of Cryptococcus neoformans have also been discussed.
【作者单位】：中国科学院微生物研究所真菌学国家重点实验室;
【基金】：中国科学院微生物研究所启动基金(编号:Y454011004)资助
【分类号】：R519

【共引文献】