四联抗结核固定剂量复合剂治疗肺结核的近期疗效及安全性

发布时间：2019-01-24 08:47

【摘要】：目的探讨四联抗结核固定剂量复合剂治疗肺结核的近期疗效及安全性。方法选取2011年1月~2016年1月我院门诊及住院的初治涂阳肺结核患者50例,将其随机分为对照组与观察组,各25例。对照组采用板式组合药2H3R3E3Z3/4H3R3进行治疗,观察组采用四联抗结核固定剂量复合剂进行治疗,并比较两组患者的疗效及不良反应情况。结果治疗后,对照组治愈率为92.00%,观察组治愈率为96.00%,差异无统计学意义(P0.05);治疗第2个月末、第3个月末,两组患者痰菌阴转率比较,差异无统计学意义(P0.05);观察组空洞愈合情况优于对照组,差异有统计学意义(P0.05);两组患者治疗期间不良反应发生情况比较,差异无统计学意义(P0.05)。结论在抗结核疗效上,四联抗结核固定剂量复合剂同板式组合药差异较小,同时不良反应发生情况差异不明显,且四联抗结核固定剂量复合剂更易于治疗管理,故可在临床上进一步推广与应用。
[Abstract]:Objective to investigate the short-term efficacy and safety of anti-tuberculosis combined with a fixed dose compound in the treatment of pulmonary tuberculosis. Methods from January 2011 to January 2016, 50 newly diagnosed smear positive pulmonary tuberculosis patients in our hospital were randomly divided into control group and observation group with 25 cases each. The patients in the control group were treated with 2H3R3E3Z3/4H3R3, and the patients in the observation group were treated with quadruple antituberculous fixed dose compound, and the curative effect and adverse reactions were compared between the two groups. Results after treatment, the cure rate of the control group was 92.00 and that of the observation group was 96.00. The difference was not statistically significant (P0.05). At the end of the second month and the third month, there was no significant difference in sputum negative rate between the two groups (P0.05), while the healing of cavity in the observation group was better than that in the control group (P0.05). There was no significant difference between the two groups in the incidence of adverse reactions during treatment (P0.05). Conclusion there is no significant difference in the antituberculotic efficacy between the four antituberculotic fixed dose combinations and the plate combination agents, and the adverse reactions are not significantly different, and the quadruple antituberculotic fixed dose compound is easier to treat and manage. Therefore, it can be further popularized and applied in clinic.
【作者单位】：沛县人民医院传染科;
【分类号】：R521

【相似文献】