吸烟对肺结核患者DOTS疗效的影响

发布时间：2019-02-17 13:44

【摘要】：目的探讨吸烟对肺结核患者DOTS疗效影响。方法选择2015年1—12月间由南昌县疾病预防控制中心管理的86例初治涂阳患者作为研究对象,根据患者吸烟状况将患者分为吸烟组(n=44)和不吸烟组(n=42),所有患者均进行DOTS策略治疗,对2组患者均进行6个月观察,对比2组患者治疗2、5、6个月后痰涂片转阴状况及患者6个月后胸片病灶吸收状况。结果不吸烟组患者治疗2、5、6个月后痰涂片转阴率分别为85.7%、95.2%、100.0%,与吸烟组(56.8%、72.7%、81.8%)相比均明显较高,P0.05,差异有统计学意义。不吸烟组患者治疗6个月后胸片检查病灶吸收率85.7%与吸烟组54.5%相比明显较高,差异有统计学意义(P0.05)。吸烟组患者用药后皮疹、胃肠道反应、白细胞减少、肝功能异常发生率分别为4.5%、11.4%、11.4%、13.6%,不吸烟组分别为2.4%、9.5%、7.1%、11.9%,吸烟组患者各不良反应发生率虽略高于不吸烟组,但2组患者对比差异无统计学意义。结论吸烟将直接影响肺结核患者DOTS治疗效果,降低患者痰涂片转阴率及病灶吸收率,临床在进行肺结核防治相关宣传工作时,也需加强对吸烟危害的宣传,促进患者治疗过程中戒烟,积极防治肺结核,提高治疗效果。
[Abstract]:Objective to investigate the effect of smoking on DOTS in patients with pulmonary tuberculosis. Methods 86 newly diagnosed smear positive patients who were managed by the Center for Disease Prevention and Control in Nanchang County from January to December 2015 were selected as the study subjects. According to the smoking status of the patients, the patients were divided into smoking group (nnb44) and non-smoking group (NX42). All the patients were treated with DOTS strategy. The patients in both groups were observed for 6 months. The sputum smears turned negative after 2 months and 6 months after treatment and the absorption status of chest radiographs in both groups were compared. Results the negative rate of sputum smear in non-smoking group was 85.7 and 95.2% respectively, which was significantly higher than that in smoking group (56.8% 72.7%). The difference is statistically significant. The absorption rate of chest radiographs in non-smoking group (85.7%) was significantly higher than that in smoking group (54.5%) after 6 months of treatment (P0.05). The incidences of rash, gastrointestinal reaction, leukopenia and liver dysfunction in the smoking group were 4.5 and 11.4% respectively, while those in the non-smoking group were 2.4% and 9.5% respectively. The incidence of adverse reactions in smoking group was slightly higher than that in non-smoking group, but there was no significant difference between the two groups. Conclusion smoking will directly affect the therapeutic effect of DOTS in patients with pulmonary tuberculosis, reduce the negative rate of sputum smear and the absorption rate of focus. To promote the treatment of patients to quit smoking, active prevention and treatment of tuberculosis, improve the therapeutic effect.
【作者单位】：南昌县疾病预防控制中心结防科;
【分类号】：R521

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