不同剂量国产普瑞巴林治疗带状疱疹后神经痛临床研究

发布时间：2019-05-11 16:37

【摘要】：目的:探讨不同剂量国产普瑞巴林用于带状疱疹后神经痛(post-herpetic neuralgia,PHN)治疗的疗效与安全性。方法:45例诊断为PHN且符合纳入标准的患者经知情同意,采用随机数字表法分为小剂量组(n=15)、中剂量组(n=15)、大剂量组(n=15),分别给予225、300、450 mg/d国产普瑞巴林治疗4周。于治疗前,治疗1、2、3、4周观察患者疗效及不良反应。采用视觉模拟量表(visual analogue scale,VAS)、医院焦虑抑郁量表(hospital anxiety and depression,HAD)、医学结局研究(medical outcomes study,MOS)睡眠量表分别评估患者疼痛、焦虑与抑郁及睡眠状况。结果:3个剂量组患者治疗1、2、3、4周时VAS评分、MOS睡眠量表评分均较治疗前下降,差异有统计学意义(P0.05);治疗4周时3组患者HAD评分较治疗前也有降低,差异有统计学意义(P0.05);但3个剂量组间VAS评分、疼痛缓解疗效、MOS睡眠量表评分、HAD评分比较差异并无统计学意义(P0.05)。不良反应以头晕、口干、嗜睡为主,多为一过性。3组间比较,头晕、口干、嗜睡各不良反应间差异有统计学意义(P0.05),余不良反应间差异无统计学意义(P0.05)。结论:不同剂量国产普瑞巴林均可减轻PHN患者疼痛,改善焦虑、抑郁、睡眠,其疗效不一定为剂量依赖性,而其不良反应为轻中度且能自行缓解。
[Abstract]:Objective: to evaluate the efficacy and safety of different doses of domestic prednisone in the treatment of post-herpetic neuralgia (post-herpetic neuralgia,PHN). Methods: with informed consent, 45 patients diagnosed as PHN were randomly divided into three groups: low dose group (n = 15), middle dose group (n = 15) and high dose group (n = 15). The patients were treated with 225300450 mg/d domestic Prubalin for 4 weeks. Before treatment, 1, 2, 3, 4 weeks after treatment, the curative effect and adverse reaction were observed. Visual analogue scale (visual analogue scale,VAS), Hospital anxiety and Depression scale (hospital anxiety and depression,HAD) and Medical outcome study (medical outcomes study,MOS) were used to evaluate the pain, anxiety, depression and sleep status of the patients. Results: after 1, 2, 3, 4 weeks of treatment, the scores of VAS and MOS sleep scale were significantly lower in the three dose groups than those before treatment (P0.05). 4 weeks after treatment, the HAD scores of the three groups were also lower than those before treatment, the difference was statistically significant (P0.05). However, there was no significant difference in VAS score, pain relief effect, MOS sleep scale score and HAD score among the three dose groups (P0.05). The adverse reactions were dizziness, dry mouth, lethargy, mostly transient. There were significant differences in dizziness, dry mouth and somnolence among the three groups (P0.05), but there was no significant difference among the other adverse reactions (P0.05). Conclusion: different doses of domestic prednisolone can relieve pain, improve anxiety, depression and sleep in patients with PHN. The curative effect is not necessarily dose-dependent, but its adverse reactions are mild to moderate and can be alleviated by itself.
【作者单位】：重庆医科大学附属第一医院疼痛科;
【分类号】：R752.12

【相似文献】