更昔洛韦治疗成人传染性单核细胞增多症的回顾性研究

发布时间：2019-05-24 21:34

【摘要】：目的研究更昔洛韦治疗成人传染性单核细胞增多症的临床疗效。方法回顾性研究2010年1月—2014年12月在某院就诊的66例成人传染性单核细胞增多症患者,根据治疗药物不同分为更昔洛韦治疗组(31例)和对症治疗组(35例),分析治疗前临床特点、临床治疗效果及EBV-DNA转阴时间等指标。结果更昔洛韦治疗组患者在退热、咽痛好转、EBV-DNA转阴、淋巴结肿大消退、转氨酶恢复正常等方面的时间均较对症治疗组缩短,两组比较差异具有统计学意义(均P0.05)。两组患者在血常规恢复正常时间方面比较,差异无统计学意义(P0.05)。结论更昔洛韦治疗成人传染性单核细胞增多症抗病毒效果较好,可使患者发热、咽痛等临床症状迅速得到缓解。
[Abstract]:Objective to study the clinical effect of ganciclovir in the treatment of adult infectious mononucleosis. Methods 66 patients with infectious mononucleosis in a hospital from January 2010 to December 2014 were studied retrospectively. they were divided into ganciclovir treatment group (31 cases) and symptomatic treatment group (35 cases) according to the different drugs. The clinical characteristics, clinical treatment effect and negative conversion time of EBV-DNA before treatment were analyzed. Results the time of antipyretic, pharyngeal pain improvement, EBV-DNA negative, lymph node enlargement regression and transaminase recovery in ganciclovir treatment group were shorter than those in symptomatic treatment group, and there was significant difference between the two groups (P 0.05). There was no significant difference in the recovery time of blood routine between the two groups (P 0.05). Conclusion Ganciclovir has a good antiviral effect in the treatment of adult infectious mononucleosis and can relieve the clinical symptoms such as fever and sore throat.
【作者单位】：中日友好医院;
【分类号】：R512.7

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