慢性阻塞性肺疾病合并肺结核患者免疫功能及其细胞因子水平变化

发布时间：2019-06-05 13:26

【摘要】：目的探究慢性阻塞性肺疾病(COPD)合并肺结核患者免疫功能及其细胞因子水平变化。方法选取COPD合并肺结核(观察组)、单纯肺结核(肺结核组)、单纯COPD(COPD组)患者各50例,同时选取50例同期健康体检者作为对照组,收集各组受试者外周静脉血,检测血清NK细胞及T淋巴细胞(CD4~+、CD8~+)比例及血清细胞因子(IL-1、s IL-2R、IL-6、IFN-γ、TNF-α)表达。结果观察组、肺结核组NK细胞比例低于COPD组及对照组(P均0.05)。观察组CD4~+比例明显低于其他三组(P均0.05)。三组患者血清IL-1、IL-6、IFN-γ水平低于对照组,s IL-2R水平高于对照组(P均0.05)。观察组、COPD组血清TNF-α水平低于对照组(P均0.05)。结论 COPD合并肺结核患者存在以NK细胞、T淋巴细胞为主的免疫功能低下,且IL-1、s IL-2R、IL-6、IFN-γ细胞因子明显异常。
[Abstract]:Objective to investigate the changes of immune function and cytokines in patients with chronic obstructive pulmonary disease (COPD) complicated with pulmonary tuberculosis. Methods 50 patients with COPD complicated with pulmonary tuberculosis (observation group), 50 patients with simple pulmonary tuberculosis (pulmonary tuberculosis group) and 50 patients with COPD (COPD at the same time were selected as the control group. The peripheral venous blood of the subjects in each group was collected. The proportion of serum NK cells and T lymphocytes (CD4~, CD8~) and the expression of IL-1,s IL-2R,IL-6,IFN- 纬 (TNF- 伪) in serum were measured. Results in the observation group, the proportion of NK cells in the pulmonary tuberculosis group was lower than that in the COPD group and the control group. The proportion of CD4~ in the observation group was significantly lower than that in the other three groups. The level of serum IL-1,IL-6,IFN- 纬 in the three groups was lower than that in the control group, and the level of s-IL-2R in the three groups was higher than that in the control group. In the observation group, the level of serum TNF- 伪 in COPD group was lower than that in control group. Conclusion NK cells and T lymphocytes are the main immune function in patients with COPD complicated with pulmonary tuberculosis, and IL-1,s IL-2R,IL-6,IFN- 纬 cytokines are significantly abnormal.
【作者单位】：天津市第四中心医院;
【分类号】：R521;R563.9

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