饲粮中添加泛酸对生长獭兔肝脏脂肪代谢的影响

发布时间：2018-01-29 11:36

本文关键词： 獭兔泛酸肝脏脂肪代谢　出处：《动物营养学报》2017年06期 　论文类型：期刊论文

【摘要】：本试验旨在研究饲粮中添加泛酸对生长獭兔肝脏脂肪代谢的影响。试验选用体重相似的断奶獭兔160只,随机分为4组,每组40个重复,每个重复1只。对照组獭兔饲喂基础饲粮,试验组獭兔分别饲喂在基础饲粮中添加10、20和40 mg/kg泛酸的饲粮。预试期7 d,正试期56 d。结果表明:与对照组相比,饲粮中添加40 mg/kg泛酸显著降低了生长獭兔肩胛、胃周和肾周脂肪沉积率(P0.05);饲粮中添加10~20 mg/kg泛酸显著降低了生长獭兔肝脏中脂滴的含量(P0.05)。饲粮中泛酸添加水平对生长獭兔血浆中总胆固醇和白蛋白的含量无显著影响(P0.05);随着饲粮中泛酸添加水平的升高,生长獭兔血浆中甘油三酯的含量先降低后趋于稳定,20、40 mg/kg添加组显著低于对照组(P0.05);与对照组相比,饲粮中添加20~40 mg/kg泛酸显著升高了生长獭兔血浆中极低密度脂蛋白的含量(P0.05)。与对照组相比,饲粮中添加40 mg/kg泛酸显著增加了肝脏中激素敏感脂酶(HSL)和骨骼肌中脂肪酸转运蛋白(FATP)基因的表达量(P0.05);饲粮中添加20~40 mg/kg泛酸显著增加了肝脏中肉毒碱棕榈酰转移酶1(CPT1)基因的表达量(P0.05);饲粮中添加10~40 mg/kg泛酸显著增加了肝脏中脂肪酸合成酶(FAS)基因和骨骼肌中CPT1基因的表达量(P0.05)。综上所述,饲粮中添加泛酸影响生长獭兔肝脏内脂肪代谢,泛酸添加水平为40 mg/kg时可降低肝脏内脂肪的沉积,并能降低机体脂肪沉积率,增加骨骼肌对脂肪酸的摄取和利用。
[Abstract]:The aim of this study was to study the effect of pantothenic acid on fat metabolism in liver of growing Rex rabbits. 160 weaned rex rabbits of similar body weight were randomly divided into 4 groups with 40 repeats in each group. The control group was fed with basic diet and the experimental group was fed with 10 ~ 20 and 40 mg/kg pantothenic acid for 7 days. The results showed that 40 mg/kg pantothenic acid supplementation significantly decreased the fat deposition rate of scapula, perigastric and perirenal fat in growing Rex rabbits compared with the control group. Addition of 10 ~ 20 mg/kg pantothenic acid to diet significantly decreased lipid droplet content in liver of growing Rex rabbits (P0.05). The level of pantothenic acid in diet had no significant effect on the contents of total cholesterol and albumin in plasma of growing Rex rabbits. With the increase of pantothenic acid in diet, the content of triglyceride in plasma of growing Rex rabbits decreased first and then tended to stable at 20 ~ 40 mg/kg, which was significantly lower than that of the control group (P 0.05). Compared with the control group, the content of very low density lipoprotein (LDL-C) in plasma of growing Rex rabbits was significantly increased by adding 20 ~ 40 mg/kg pantothenic acid to the diet, compared with the control group. The addition of 40 mg/kg pantothenic acid in diet significantly increased the expression of HSLs in liver and FATP in skeletal muscle. The addition of 20 ~ 40 mg/kg pantothenic acid in diet significantly increased the expression of carnitine palmitoyltransferase 1 (CPT1) gene in liver. The addition of 10 ~ 40 mg/kg pantothenic acid in diet significantly increased the expression of fatty acid synthase (FAS) gene in liver and CPT1 gene in skeletal muscle. The addition of pantothenic acid in diet affected the fat metabolism in liver of growing Rex rabbits. When the level of pantothenic acid was 40 mg/kg, the fat deposition in liver was decreased and the fat deposition rate was decreased. Increase the uptake and utilization of fatty acids in skeletal muscle.
【作者单位】：山东农业大学动物科技学院;
【基金】：中国博士后科学基金项目(2015M58061) 山东农业大学青年科技创新基金项目(2015—2016);山东农业大学博士后科学基金项目(2015—2017) 现代农业产业技术体系建设专项(CARS-44-B-1)
【分类号】：S829.1
【正文快照】： 肝脏是脂类代谢的重要场所,在脂类的消化、吸收、合成、分解、转运等过程中起重要作用。肝脏以乙酰辅酶A(acetyl-Co A)为原料合成脂肪酸,脂肪酸的合成过程还受到脂肪酸合成酶类[如脂肪酸合成酶(FAS)、苹果酸脱氢酶]的调节[1]。肝脏内脂类也发生脂解作用,为肝细胞提供能量。脂

【相似文献】