孕酮与雌激素对犬子宫组织炎症发生的作用机制研究

发布时间：2018-02-16 08:04

本文关键词： 犬子宫炎症 NF-κB MAPKs 炎性因子孕酮雌激素　出处：《黑龙江畜牧兽医》2017年15期 　论文类型：期刊论文

【摘要】：为了研究犬子宫组织炎症的损伤情况,探讨激素对子宫炎症的影响及作用机制,试验选取临床患病犬及健康犬为动物模型,采用病理学观察、荧光定量分析、蛋白免疫印迹等方法检测犬孕酮、雌激素分泌情况及子宫组织的相关炎症指标。结果表明:孕酮会促进NF-κB及MAPKs信号通路各分子磷酸化,促进子宫组织炎症损伤及促炎因子分泌;雌激素则抑制NF-κB及MAPKs信号通路各分子磷酸化,降低相关炎症因子产生。说明犬子宫炎症发生过程中孕酮促进疾病的发生,雌激素却可以有效地保护子宫组织、降低炎症损伤。
[Abstract]:In order to study the injury of uterine inflammation in dogs and to explore the effect and mechanism of hormones on uterine inflammation, the clinical and healthy dogs were selected as animal models, the pathological observation and fluorescence quantitative analysis were used. Western blot was used to detect progesterone, estrogen secretion and related inflammatory indexes of uterine tissue. The results showed that progesterone could promote phosphorylation of NF- 魏 B and MAPKs signaling pathway, promote inflammation injury and secretion of pro-inflammatory factor in uterine tissue. Estrogen inhibits the phosphorylation of NF- 魏 B and MAPKs signaling pathway molecules and reduces the production of related inflammatory factors, indicating that progesterone promotes the occurrence of diseases during the development of uterine inflammation in dogs, but estrogen can effectively protect uterine tissues and reduce inflammatory injury.
【作者单位】：吉林大学动物医学学院;河南牧业经济学院动物医学院;
【基金】：国家自然科学基金项目“TLR4信号转导干预调控奶牛乳腺炎症反应的研究”(312726221)
【分类号】：S858.292

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